癌症与发育过程中PAX基因全景图

A PANorama of PAX genes in cancer and development.

作者信息

Robson Ewan J D, He Shu-Jie, Eccles Michael R

机构信息

Department of Pathology, University of Otago, PO Box 913, Dunedin 9001, New Zealand.

出版信息

Nat Rev Cancer. 2006 Jan;6(1):52-62. doi: 10.1038/nrc1778.

DOI:10.1038/nrc1778

PMID:16397527

Abstract

Populations of self-renewing cells that arise during normal embryonic development harbour the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour generation. So, control mechanisms are essential to prevent rapidly expanding populations from malignant growth. Transcription factors have crucial roles in ensuring establishment of such regulation, with the Pax gene family prominent amongst these. This review examines the role of Pax family members during embryogenesis, and their contribution to tumorigenesis when subverted.

摘要

在正常胚胎发育过程中出现的自我更新细胞群体具有快速增殖、迁移或转分化的潜力，因此也具有产生肿瘤的可能性。所以，控制机制对于防止快速扩张的细胞群体发生恶性生长至关重要。转录因子在确保建立这种调控方面发挥着关键作用，其中Pax基因家族尤为突出。本综述探讨了Pax家族成员在胚胎发生过程中的作用，以及它们在功能被破坏时对肿瘤发生的影响。