情绪学习与谷氨酸：转化医学视角
Emotional learning and glutamate: translational perspectives.
作者信息
Gillespie Charles F, Ressler Kerry J
机构信息
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA.
出版信息
CNS Spectr. 2005 Oct;10(10):831-9. doi: 10.1017/s1092852900010439.
Abstract
Anxiety disorders are a common focus of clinical concern and certain forms of anxiety may be conceptualized as disorders of emotional learning. Behavior therapies effective in the treatment of anxiety are modeled on extinction training as a means of reducing pathological anxiety. The present understanding of human anxiety has been informed by preclinical research using rodent models to study the acquisition and extinction of fear. Glutamate appears to have a central role in both of these processes. The authors review this literature and discuss novel applications of D-cycloserine, a partial N-methyl-D-aspartate agonist, for the treatment of anxiety.
摘要
焦虑症是临床关注的常见焦点，某些形式的焦虑可被概念化为情绪学习障碍。对治疗焦虑有效的行为疗法是以消退训练为模型，作为减少病理性焦虑的一种手段。目前对人类焦虑的理解得益于临床前研究，该研究使用啮齿动物模型来研究恐惧的习得和消退。谷氨酸似乎在这两个过程中都起着核心作用。作者回顾了这一文献，并讨论了D-环丝氨酸（一种部分N-甲基-D-天冬氨酸激动剂）在治疗焦虑方面的新应用。
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本文引用的文献
1
D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction.
Biol Psychiatry. 2005 Apr 15;57(8):841-7. doi: 10.1016/j.biopsych.2005.01.023.
2
Glutamate receptor antagonist infusions into the basolateral and medial amygdala reveal differential contributions to olfactory vs. context fear conditioning and expression.
Learn Mem. 2005 Mar-Apr;12(2):120-9. doi: 10.1101/lm.87105. Epub 2005 Mar 17.
3
Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats.
Learn Mem. 2005 Mar-Apr;12(2):130-7. doi: 10.1101/lm.85304. Epub 2005 Mar 17.
4
Postsynaptic receptor trafficking underlying a form of associative learning.
Science. 2005 Apr 1;308(5718):83-8. doi: 10.1126/science.1103944. Epub 2005 Mar 3.
5
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.
J Neurosci. 2005 Jan 26;25(4):977-84. doi: 10.1523/JNEUROSCI.4059-04.2005.
6
Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.
Psychopharmacology (Berl). 2005 Apr;179(1):284-91. doi: 10.1007/s00213-004-2098-x. Epub 2004 Dec 24.
7
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.
Arch Gen Psychiatry. 2004 Nov;61(11):1136-44. doi: 10.1001/archpsyc.61.11.1136.
8
Context and behavioral processes in extinction.
Learn Mem. 2004 Sep-Oct;11(5):485-94. doi: 10.1101/lm.78804.
9
Extinction learning in humans: role of the amygdala and vmPFC.
Neuron. 2004 Sep 16;43(6):897-905. doi: 10.1016/j.neuron.2004.08.042.
10
The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.
Neuropsychopharmacology. 2004 Nov;29(11):1971-9. doi: 10.1038/sj.npp.1300540.
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