Struzik Zbigniew R, Hayano Junichiro, Soma Rika, Kwak Shin, Yamamoto Yoshiharu
Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Japan.
IEEE Trans Biomed Eng. 2006 Jan;53(1):89-94. doi: 10.1109/TBME.2005.859801.
We reveal unexpected origins of age induced departure from 1/f-type temporal scaling in healthy human heart rate. Contrary to the widely established view, we provide evidence that age induced dynamical imbalance in the autonomic control is not due to the emergent functional dominance of the sympathetic nervous system (SNS), but due to emerging (age dependent) relative dynamic dominance of the parasympathetic nervous system function. In particular, we demonstrate that the age induced alterations of healthy heart rate dynamics asymptotically resemble those in so-called primary autonomic failure with neurogenic SNS dysfunction and in other neurodegenerative disorders, including Parkinson's disease even without known autonomic abnormalities. Based upon this, we propose a novel picture of "autonomic aging," characterized by an insufficiency of the SNS function to cope dynamically with various environmental stimuli.
我们揭示了健康人心率中年龄诱导的偏离1/f型时间尺度的意外起源。与广泛确立的观点相反，我们提供的证据表明，年龄诱导的自主控制动态失衡并非由于交感神经系统（SNS）出现功能优势，而是由于副交感神经系统功能出现（与年龄相关的）相对动态优势。特别是，我们证明，年龄诱导的健康心率动态变化渐近类似于所谓的原发性自主神经功能衰竭伴神经源性SNS功能障碍以及其他神经退行性疾病（包括帕金森病，即使没有已知的自主神经异常）中的变化。基于此，我们提出了一种“自主神经衰老”的新图景，其特征是SNS功能不足以动态应对各种环境刺激。
