Terada Keith Y, Shimizu David M, Jiang Caroline S, Wong Jan H
Department of Obstetrics and Gynecology, University of Hawaii School of Medicine, Honolulu, HI 96822, USA.
Gynecol Oncol. 2006 Aug;102(2):200-3. doi: 10.1016/j.ygyno.2005.11.042. Epub 2006 Jan 9.
This retrospective review was undertaken to evaluate survival in patients with T1 squamous cell carcinoma of the vulva treated with radical local excision and sentinel node dissection.
Patients with T1 cancers underwent pre-operative lymphoscintigraphy and sentinel lymph node dissection using technetium sulfur colloid and isosulfan blue dye. The primary tumor was removed with radical local excision. Patients with negative sentinel nodes did not receive any additional treatment. Survival was calculated using life table analysis.
There were 21 patients who underwent 27 sentinel node dissections. Three patients were found to have positive sentinel nodes. At a median follow-up of 4.6 years, two patients have died of cancer, and three patients have died of intercurrent illness. None of the patients with negative sentinel nodes has died of cancer. There were no groin or distant recurrences in patients with negative sentinel nodes. Three-year disease-free survival for all patients and for patients with negative sentinel nodes were 90% and 100% respectively.
The survival for patients with early vulvar cancer treated with sentinel node dissection and radical local excision appears excellent.
进行这项回顾性研究以评估接受根治性局部切除和前哨淋巴结清扫术治疗的T1期外阴鳞状细胞癌患者的生存率。
T1期癌症患者术前行淋巴闪烁显像，并使用硫化锝胶体和异硫蓝染料进行前哨淋巴结清扫。原发性肿瘤通过根治性局部切除去除。前哨淋巴结阴性的患者未接受任何额外治疗。采用生命表分析法计算生存率。
21例患者接受了27次前哨淋巴结清扫。发现3例患者前哨淋巴结阳性。中位随访4.6年时，2例患者死于癌症，3例患者死于并发疾病。前哨淋巴结阴性的患者均未死于癌症。前哨淋巴结阴性的患者无腹股沟或远处复发。所有患者和前哨淋巴结阴性患者的3年无病生存率分别为90%和100%。
接受前哨淋巴结清扫和根治性局部切除治疗的早期外阴癌患者生存率似乎良好。
