Wagner Victoria E, Frelinger John G, Barth Richard K, Iglewski Barbara H
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Trends Microbiol. 2006 Feb;14(2):55-8. doi: 10.1016/j.tim.2005.12.002. Epub 2006 Jan 6.
A recent study suggests that the opportunistic pathogen Pseudomonas aeruginosa can actively monitor the host immune system. The P. aeruginosa outer membrane protein OprF was found to bind specifically to the cytokine interferon-gamma (IFN-gamma), and this interaction upregulated production of virulence factors through a cell-cell communication system known as quorum sensing (QS). Taken together with previous findings that P. aeruginosa QS can alter the host immune response (e.g. by activation of IFN-gamma), these data illustrate an exciting new element of bacteria-host interactions in which the P. aeruginosa quorum-sensing system both senses and modulates the host immune state.
最近的一项研究表明，机会致病菌铜绿假单胞菌能够主动监测宿主免疫系统。研究发现，铜绿假单胞菌外膜蛋白OprF能特异性结合细胞因子γ干扰素（IFN-γ），这种相互作用通过一种称为群体感应（QS）的细胞间通讯系统上调毒力因子的产生。结合之前关于铜绿假单胞菌群体感应可改变宿主免疫反应（如通过激活IFN-γ）的研究结果，这些数据揭示了细菌与宿主相互作用中一个令人兴奋的新元素，即铜绿假单胞菌群体感应系统既能感知又能调节宿主免疫状态。
