将结肠镜下过敏原激发试验作为确诊食物过敏反应犬的诊断工具的评估。
Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions.
作者信息
Allenspach K, Vaden S L, Harris T S, Gröne A, Doherr M G, Griot-Wenk M E, Bischoff S C, Gaschen F
机构信息
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
出版信息
J Small Anim Pract. 2006 Jan;47(1):21-6. doi: 10.1111/j.1748-5827.2006.00007.x.
OBJECTIVE
To evaluate the colonoscopic allergen provocation (COLAP) test as a new tool for the diagnosis of IgE-mediated food allergy.
METHODS
Oral food challenges as well as COLAP testing were performed in a colony of nine research dogs with proven immediate-type food allergic reactions. In addition, COLAP was performed in five healthy dogs.
RESULTS
When compared with the oral challenge test, COLAP accurately determined 18 of 23 (73 per cent) positive oral challenge reactions (73 per cent) in dogs with food allergies and was negative in the healthy dogs.
CLINICAL SIGNIFICANCE
The accuracy of this new test may be higher than that for gastric sensitivity testing. Therefore, COLAP holds promise as a new test to confirm the diagnosis of suspect IgE-mediated food allergy in dogs.
目的
评估结肠镜过敏原激发试验（COLAP）作为诊断IgE介导的食物过敏的新工具。
方法
对9只经证实有速发型食物过敏反应的实验犬进行口服食物激发试验和COLAP检测。此外，对5只健康犬进行COLAP检测。
结果
与口服激发试验相比，COLAP准确判定了23只食物过敏犬中18只（73%）口服激发试验阳性反应（73%），且在健康犬中呈阴性。
临床意义
这项新检测的准确性可能高于胃敏感性检测。因此，COLAP有望成为一种新的检测方法，用于确诊疑似IgE介导的犬食物过敏。
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