Parr Jeremy R, Salama Amanda, Sebire Peter
Department of Paediatrics, Wexham Park Hospital, Slough, SL2 4HL, UK.
Eur J Pediatr. 2006 May;165(5):323-5. doi: 10.1007/s00431-005-0049-0. Epub 2006 Jan 19.
British Thoracic Society guidelines recommend intravenous salbutamol or aminophylline for acute severe asthma in children. In the survey reported here, 133 consultant paediatricians completed a questionnaire aimed at evaluating their choice of intravenous bronchodilator for acute severe asthma and their awareness of subsequent hypokalaemia. Of the non-Paediatric Intensive Care Unit (PICU) consultants who responded, 82%, including respiratory paediatricians, reported using aminophylline; in contrast, PICU consultants were significantly more likely to use salbutamol (p=<0.001). There was a lack of awareness that hypokalaemia occurs with aminophylline: 50% of the consultants suggested that hypokalaemia was rare or did not occur. Consultants using intravenous aminophylline were significantly less likely to recheck serum potassium levels than those using intravenous salbutamol (p=0.03). Based on the completed questionnaires, salbutamol infusions are rarely used outside the PICU, and the awareness of potential hypokalaemia following intravenous bronchodilator treatment is variable. It would appear, therefore, that standardised clinical practice is required in order to recognise and treat potential hypokalaemia.
英国胸科学会指南推荐使用静脉注射沙丁胺醇或氨茶碱治疗儿童急性重症哮喘。在本文报道的这项调查中,133名儿科顾问医师填写了一份问卷,旨在评估他们对急性重症哮喘静脉支气管扩张剂的选择以及对随后发生低钾血症的认知情况。在回复的非儿科重症监护病房(PICU)顾问医师中,包括呼吸科儿科医师在内,82%的人报告使用氨茶碱;相比之下,PICU顾问医师使用沙丁胺醇的可能性显著更高(p<0.001)。对于氨茶碱会导致低钾血症这一点缺乏认知:50%的顾问医师认为低钾血症很少见或不会发生。与使用静脉注射沙丁胺醇的顾问医师相比,使用静脉注射氨茶碱的顾问医师复查血清钾水平的可能性显著更低(p=0.03)。根据填写完整的问卷,PICU之外很少使用沙丁胺醇静脉滴注,并且对静脉支气管扩张剂治疗后潜在低钾血症的认知存在差异。因此,似乎需要标准化的临床实践来识别和治疗潜在的低钾血症。