Colson P, Galy A, Grolleau D, Séguin J, Saussine M, Cuchet D, Chaptal P A, Roquefeuil B
Département d'Anesthésie, Hôpital St-Eloi, Montpellier, France.
Br J Anaesth. 1992 Apr;68(4):420-1. doi: 10.1093/bja/68.4.420.
We have studied the cardiovascular effects of nitrous oxide after cardiac ischaemia-reperfusion injury caused by aortic cross-clamping and unclamping during coronary artery bypass grafting (CABG). At the time of chest closure, 20 patients were allocated randomly to receive oxygen and air (FIO2 = 0.5) or 50% nitrous oxide in oxygen in addition to anaesthesia with fentanyl. Nitrous oxide significantly decreased mean arterial pressure (P less than 0.01) and cardiac index (P less than 0.05), which suggests that nitrous oxide with fentanyl may significantly depress left ventricular performance after CABG. Although ischaemia-reperfusion cardiac injury did not appear to increase the myocardial depressant effect of nitrous oxide, the use of nitrous oxide is not recommended immediately after CABG.
我们研究了在冠状动脉旁路移植术（CABG）期间主动脉交叉夹闭和松开所导致的心脏缺血-再灌注损伤后，一氧化二氮对心血管系统的影响。在关胸时，20例患者被随机分配，一组接受氧气和空气（吸入氧分数=FIO2 = 0.5），另一组除接受芬太尼麻醉外，还接受50%一氧化二氮与氧气混合气体。一氧化二氮显著降低了平均动脉压（P<0.01）和心脏指数（P<0.05），这表明一氧化二氮与芬太尼联用可能会在CABG后显著抑制左心室功能。虽然缺血-再灌注性心脏损伤似乎并未增加一氧化二氮的心肌抑制作用，但不建议在CABG后立即使用一氧化二氮。
