阳性活检部位作为根治性前列腺切除术中手术切缘状态和前列腺外疾病的预测指标
Location of a positive biopsy as a predictor of surgical margin status and extraprostatic disease in radical prostatectomy.
作者信息
Touma Naji J, Chin Joseph L, Bella Tony, Sener Alp, Izawa Jonathan I
机构信息
Surgery, Division of Urology, University of Western Ontario, London, Ontario, Canada.
出版信息
BJU Int. 2006 Feb;97(2):259-62. doi: 10.1111/j.1464-410X.2006.05968.x.
OBJECTIVE
To investigate whether the location of preoperative biopsy positive cores can identify patients at higher risk of a positive surgical margin (SM) and extraprostatic extension (EPE) at radical retropubic prostatectomy (RRP).
PATIENTS AND METHODS
We retrospectively reviewed the clinical and pathological data of 371 patients who had a RRP for biopsy confirmed prostate cancer between January 2000 and October 2003.
RESULTS
A positive biopsy at the apex was not predictive of a positive apical SM or EPE. However, a positive biopsy at the base was predictive of a positive basal SM and EPE. A positive SM, in turn, correlated with EPE on final pathology. Positive basal SM correlated with EPE in 75% of cases whereas positive apical SM showed EPE in only 33% (P < 0.02).
CONCLUSION
A positive biopsy core at the base appears to correlate with a positive basal SM and EPE. A positive basal SM correlates with EPE at a higher rate than apical SMs.
目的
探讨术前活检阳性芯块的位置能否识别耻骨后根治性前列腺切除术（RRP）时手术切缘阳性（SM）和前列腺外侵犯（EPE）风险较高的患者。
患者与方法
我们回顾性分析了2000年1月至2003年10月间371例行RRP且活检确诊为前列腺癌患者的临床和病理资料。
结果
尖部活检阳性不能预测尖部SM阳性或EPE。然而，底部活检阳性可预测底部SM阳性和EPE。而最终病理显示，阳性SM与EPE相关。底部SM阳性在75%的病例中与EPE相关，而尖部SM阳性仅在33%的病例中显示EPE（P<0.02）。
结论
底部活检阳性芯块似乎与底部SM阳性和EPE相关。底部SM阳性与EPE相关的比例高于尖部SM阳性。
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