丁丙诺啡在海洛因成瘾治疗中的作用。
Role of buprenorphine in the management of heroin addiction.
作者信息
Sung Soojin, Conry John M
机构信息
Department of Pharmacy, Bronx Veterans Affairs Medical Center, NY, USA.
出版信息
Ann Pharmacother. 2006 Mar;40(3):501-5. doi: 10.1345/aph.1G276. Epub 2006 Jan 24.
OBJECTIVE
To review buprenorphine and explore its role in the treatment of heroin dependence.
DATA SOURCES
Articles were identified through a search of MEDLINE (1966-February 2005) using the key terms buprenorphine, heroin, opioid, addiction, and methadone.
DATA SYNTHESIS
Buprenorphine appears to provide potential advantages over methadone. Two Cochrane meta-analyses were evaluated on the use of buprenorphine in opioid dependence-one in the management of opioid dependence and the other in the management of opioid withdrawal.
CONCLUSIONS
Buprenorphine offers several advantages for the treatment of heroin addiction. As maintenance treatment, buprenorphine is effective, but not more effective than methadone. In the management of opioid withdrawal, buprenorphine may be better tolerated than clonidine or methadone.
目的
回顾丁丙诺啡并探讨其在海洛因依赖治疗中的作用。
资料来源
通过检索MEDLINE（1966年 - 2005年2月），使用关键词丁丙诺啡、海洛因、阿片类药物、成瘾和美沙酮来确定文章。
资料综合
丁丙诺啡似乎比美沙酮具有潜在优势。对两项Cochrane荟萃分析进行了评估，一项是关于丁丙诺啡在阿片类药物依赖管理中的应用，另一项是在阿片类药物戒断管理中的应用。
结论
丁丙诺啡在海洛因成瘾治疗方面具有多个优势。作为维持治疗，丁丙诺啡有效，但不比美沙酮更有效。在阿片类药物戒断管理中，丁丙诺啡可能比可乐定或美沙酮耐受性更好。
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