Ramacciato Giovanni, Varotti Giovanni, Quintini Cristiano, Masetti Michele, Di Benedetto Fabrizio, Grazi Gian Luca, Ercolani Giorgio, Cescon Matteo, Ravaioli Matteo, Lauro Augusto, Pinna Antonio
Department of Surgery and Transplantations, Liver and Multiorgan Transplantation Unit, S.Orsola Hospital, University of Bologna, Italy.
Transpl Int. 2006 Feb;19(2):122-7. doi: 10.1111/j.1432-2277.2005.00248.x.
Biliary reconstruction is one of the most challenging parts of right lobe living donor liver transplantation (RL LDLT), and biliary complications have been reported as the first source of surgical complications of this procedure. We reviewed biliary reconstruction and complications in 27 consecutive RL LDLTs. We compared the first 14 procedures (group 1) to the last 13 (group 2). Seven patients (25.9%) experienced a biliary complication (five leaks and two strictures). The incidence of biliary complications was 11.1% in RL grafts with a single duct and 55.5% in graft presenting multiple bile ducts (P = 0.03). Four of the 18 patients with a duct-to-duct reconstruction (22.2%) and three of the 11 patients with a Roux-en-Y reconstruction (27.3%) developed a biliary complication (P = ns). The incidence of biliary complications significantly decreased from 42.9% (n = 6) in the first group to 7.6% (n = 1) in the second group (P = 0.05). The overall 1-year graft and patient survival were 57.1% and 64.3% in group 1 versus 100.0% and 100% in group 2 (P = 0.01; P = 0.006). Biliary complications remain one of the most important technical complications affecting RL LDLT. Nevertheless, attention and surgical refinement can lead to a significant reduction of the biliary complication rate, improving graft and patient survival.
胆管重建是右半肝活体供肝移植(RL LDLT)中最具挑战性的部分之一,据报道,胆管并发症是该手术外科并发症的首要来源。我们回顾了连续27例RL LDLT的胆管重建及并发症情况。我们将前14例手术(第1组)与后13例(第2组)进行了比较。7例患者(25.9%)发生了胆管并发症(5例渗漏和2例狭窄)。单支胆管的RL移植物中胆管并发症发生率为11.1%,多支胆管的移植物中为55.5%(P = 0.03)。18例胆管对胆管重建患者中有4例(22.2%)、11例Roux-en-Y重建患者中有3例(27.3%)发生了胆管并发症(P = 无显著差异)。胆管并发症发生率从第1组的42.9%(n = 6)显著降至第2组的7.6%(n = 1)(P = 0.05)。第1组1年移植物和患者生存率分别为57.1%和64.3%,而第2组为100.0%和100%(P = 0.01;P = 0.006)。胆管并发症仍然是影响RL LDLT的最重要技术并发症之一。然而,通过关注和手术改进可显著降低胆管并发症发生率,提高移植物和患者生存率。