Tseng L-H, Lin M-T, Shau W-Y, Lin W-C, Chang F-Y, Chien K-L, Hansen J A, Chen D-S, Chen P-J
Department of Medical Genetics and Internal Medicine, National Taiwan University Hospital, and Graduate Institutes of Clinical Medicine, National Taiwan University, Taipei, Taiwan.
Tissue Antigens. 2006 Feb;67(2):127-33. doi: 10.1111/j.1399-0039.2006.00536.x.
Polymorphisms in cytokine genes can influence immune responses, inflammation and tissue injury, and may affect the outcome of hepatitis B virus (HBV) infection. We analyzed single nucleotide polymorphisms (SNP) in the interleukin (IL)-10 gene among 344 HBV carriers and 208 patients with hepatocellular carcinoma (HCC). Genotypes and haplotypes were tested for association with HCC. IL-10/-592 C/C genotype was associated with a higher risk for HCC compared with IL-10/-592 A/C and A/A genotypes [odds ratio (OR): 2.1, 95% confidence interval (CI): 1.2-3.6]. IL-10/1927 A/A genotype was also associated with a higher risk for HCC compared with IL-10/1927 A/C and C/C genotypes (OR: 1.5, 95% CI: 1.0-2.2). Haplotype analysis revealed that the homozygosity of the C-A haplotype (defined by SNPs at positions -592 and 1927) of IL-10 gene conveys the highest risk for HCC among HBV carriers compared with the homozygosity for the A-C haplotype (OR: 2.6, 95% CI: 1.3-4.9). The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection. Further studies are necessary to clarify how variation in the IL-10 gene affects IL-10 function and risk of HCC.
细胞因子基因多态性可影响免疫反应、炎症和组织损伤，并可能影响乙型肝炎病毒（HBV）感染的结局。我们分析了344例HBV携带者和208例肝细胞癌（HCC）患者白细胞介素（IL）-10基因中的单核苷酸多态性（SNP）。检测了基因型和单倍型与HCC的关联性。与IL-10 / -592 A/C和A/A基因型相比，IL-10 / -592 C/C基因型与HCC的较高风险相关[比值比（OR）：2.1，95%置信区间（CI）：1.2 - 3.6]。与IL-10 / 1927 A/C和C/C基因型相比，IL-10 / 1927 A/A基因型也与HCC的较高风险相关（OR：1.5，95% CI：1.0 - 2.2）。单倍型分析显示，与A-C单倍型纯合子相比，IL-10基因的C-A单倍型（由-592和1927位的SNP定义）纯合子在HBV携带者中具有最高的HCC风险（OR：2.6，95% CI：1.3 - 4.9）。结果表明，IL-10基因多态性可影响慢性HBV感染的结局。有必要进一步研究以阐明IL-10基因变异如何影响IL-10功能和HCC风险。
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