抗体增强了在经口感染兔脑炎微孢子虫的重症联合免疫缺陷（SCID）小鼠中CD4 + T淋巴细胞的保护作用。

Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi.

作者信息

Sak B, Salát J, Horká H, Saková K, Ditrich O

机构信息

Institute of Parasitology, Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceské Budejovice, Czech Republic.

出版信息

Parasite Immunol. 2006 Mar;28(3):95-9. doi: 10.1111/j.1365-3024.2005.00813.x.

DOI:10.1111/j.1365-3024.2005.00813.x

PMID:16441507

Abstract

The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.

摘要

使用一种新型抗外孢子单克隆抗体（MAb）P5/H1研究了抗体在微孢子虫病免疫反应中的作用，该抗体可识别兔脑炎微孢子虫的表面抗原。MAb对体内微孢子虫感染的作用是延长先前经CD4+重建、经口感染并经腹腔注射MAb治疗的SCID小鼠的存活时间。MAb减少了死后获得的腹膜涂片上兔脑炎微孢子虫孢子的数量。这些结果表明抗体在预防经口获得的兔脑炎微孢子虫感染中可能发挥作用。