Almas Aysha, Hameed Aamir, Ahmed Bilal, Islam Muhammad
Department of Medicine, The Aga Khan University, Stadium Road, Karachi.
J Coll Physicians Surg Pak. 2006 Jan;16(1):23-6.
To determine compliance, factors affecting compliance to antihypertensive therapy and to compare compliant and non-compliant groups, in a tertiary care setting.
Analytical (cross-sectional) study.
The outpatient clinics at the Aga Khan University from May 2004 to February 2005.
Two hundred patients presenting to the outpatients clinic were included. All patients 18 years and above, who had stage 1 and 2 hypertension, had one clinic visit to a medicine clinic, 6 months prior to presentation and started on antihypertensive medicines, were included.
Sixty six percent were males and 33.5 % were females. Mean age was 58.1(+/-12) years and mean duration of hypertension was 7.2 (+/- 6.7) years. Fifty-seven percent were compliant and 43 % were noncompliant. In the noncompliant group, 53.4 % had mild noncompliance, 24.4 % had severe non-compliance, while 22% had moderate noncompliance. Factors of noncompliance were 56.8% missed doses due to forgetfulness, 12.7% deliberately missed their doses, 11.6% could not take the medicine due to side effects, 10.4% did not take the dose due to increased number of tablets, 4.6% were not properly counseled by the physician and 3.48% did not take medicines due to cost issues. The mean systolic blood pressure was 126 +/- 19.2 mmHg in the compliant group while it was 133 +/-16.5 mmHg in the noncompliant group p-value 0.004). The mean diastolic blood pressure in the compliant group was 76 +/- 11.9 mmHg, while in the noncompliant group it was 81.9 +/-10.9 mmHg (p-value 0.001).
Compliance to antihypertensive therapy in a tertiary care center is significantly good. Forgetfulness was the major reason for noncompliance. The mean blood pressure control was better in the compliant group.
在三级医疗环境中，确定抗高血压治疗的依从性、影响依从性的因素，并比较依从组和不依从组。
分析性（横断面）研究。
2004年5月至2005年2月在阿迦汗大学门诊诊所。
纳入200名到门诊就诊的患者。所有18岁及以上、患有1期和2期高血压、在就诊前6个月曾到内科门诊就诊并开始服用抗高血压药物的患者均被纳入。
男性占66%，女性占33.5%。平均年龄为58.1（±12）岁，高血压平均病程为7.2（±6.7）年。57%的患者依从，43%的患者不依从。在不依从组中，53.4%为轻度不依从，24.4%为重度不依从，22%为中度不依从。不依从的因素包括：56.8%因遗忘漏服药物，12.7%故意漏服药物，11.6%因副作用无法服药，10.4%因药片数量增加未服药，4.6%未得到医生适当指导，3.48%因费用问题未服药。依从组的平均收缩压为126±19.2 mmHg，不依从组为133±16.5 mmHg（p值0.004）。依从组的平均舒张压为76±11.9 mmHg，不依从组为81.9±10.9 mmHg（p值0.001）。
三级医疗中心抗高血压治疗的依从性显著良好。遗忘是不依从的主要原因。依从组的平均血压控制更好。
