Kerur Basavaraj M, Vishnu Bhat B, Harish B N, Habeebullah S, Uday Kumar C
Department of Pediatrics,Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Indian J Pediatr. 2006 Jan;73(1):29-32. doi: 10.1007/BF02758256.
The study was intended to evaluate the role of maternal genital bacteria and baby's surface colonization in early onset neonatal sepsis.
Babies (born in the hospital of Jawaharlal Institute of Postgraduate Medical Education and Research) who developed clinical signs of sepsis were studied. Swabs were collected for culture from baby's umbilicus, ear, throat in addition to gastric aspirate and blood culture. The genital tract of the mother was also studied for bacterial colonization. The organisms isolated from the maternal genital tract and baby's surface colonization were correlated with those isolated from blood culture by calculating Phi correlation coefficient.
Esch coli was the most common organism isolated from maternal genital tract and surface cultures of babies, but Klebseilla-Spp was the most common organism isolated from blood. There was a significant correlation between surface colonization of babies and maternal genital bacteria, so also was baby's surface culture and blood culture. However, correlation between maternal genital bacteria and baby's blood culture was not significant.
Surface colonizing bacteria and not maternal genital bacteria are important in early onset neonatal sepsis.
本研究旨在评估母体生殖道细菌和婴儿体表定植菌在早发型新生儿败血症中的作用。
对（在贾瓦哈拉尔研究生医学教育与研究学院医院出生的）出现败血症临床症状的婴儿进行研究。除了采集胃吸出物和血培养样本外，还从婴儿的脐带、耳朵、喉咙处采集拭子进行培养。同时也对母亲的生殖道进行细菌定植情况研究。通过计算Phi相关系数，将从母体生殖道和婴儿体表定植中分离出的微生物与从血培养中分离出的微生物进行相关性分析。
大肠杆菌是从母体生殖道和婴儿体表培养物中分离出的最常见微生物，但克雷伯菌属是从血液中分离出的最常见微生物。婴儿体表定植菌与母体生殖道细菌之间存在显著相关性，婴儿体表培养物与血培养之间也存在显著相关性。然而，母体生殖道细菌与婴儿血培养之间的相关性不显著。
在早发型新生儿败血症中，体表定植菌而非母体生殖道细菌起重要作用。
