MR imaging of nephropathies.

Acute and chronic nephropathies are responsible for morphologic and functional renal changes. However, radiologic techniques currently play a minor role in imaging of parenchymal nephropathies in native or transplanted kidneys. From a morphologic point of view, three-dimensional magnetic resonance (MR) volumetric biomarkers of kidney function, such as renal and cortical volumes or cystic volume, in polycystic kidney diseases play a growing role in nephrologic practice. From a functional point of view, if scintigraphic techniques remain the major sources of renal performance assessment, new MR imaging systems and specific MR contrast agents may soon provide significant developments in the evaluation of renal performance (glomerular filtration rate measurement), in the search for prognostic factors (hypoxia, inflammation, cell viability, degree of tubular function, and interstitial fibrosis), and for monitoring new cell therapies. New developments that have provided higher signal-to-noise ratio and higher spatial and/or temporal resolutions have the potential to direct new opportunities for obtaining morphologic and functional information on tissue characteristics that are relevant for various renal diseases with respect to diagnosis, prognosis, and treatment follow-up.