Spears Kevin J, Roe Andrew J, Gally David L
Zoonotic and Animal Pathogens Research Laboratory, Centre for Infectious Diseases, Chancellor's Building, University of Edinburgh, Edinburgh, UK.
FEMS Microbiol Lett. 2006 Feb;255(2):187-202. doi: 10.1111/j.1574-6968.2006.00119.x.
This review covers enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) infections, focusing on differences in their virulence factors and regulation. While Shiga-toxin expression from integrated bacteriophages sets EHEC apart from EPEC, EHEC infections often originate from asymptomatic carriage in ruminants whereas human EPEC are considered to be overt pathogens and more host-restricted. In part, these differences reflect variation in adhesin repertoire, type III-secreted effectors and the way in which these factors are regulated.
本综述涵盖了肠致病性大肠杆菌（EPEC）和肠出血性大肠杆菌（EHEC）感染，重点关注它们毒力因子和调控方面的差异。虽然整合噬菌体产生的志贺毒素表达使EHEC有别于EPEC，但EHEC感染通常源于反刍动物的无症状携带，而人类EPEC被认为是显性病原体且宿主限制性更强。这些差异部分反映了黏附素种类、III型分泌效应蛋白以及这些因子调控方式的变化。
