Anderson Graham, Jenkinson William E, Jones Terry, Parnell Sonia M, Kinsella Francesca A M, White Andrea J, Pongrac'z Judit E, Rossi Simona W, Jenkinson Eric J
MRC Center for Immune Regulation, Division of Immunity and Infection, Institute For Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK.
Immunol Rev. 2006 Feb;209:10-27. doi: 10.1111/j.0105-2896.2006.00347.x.
The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.
胸腺支持从未成熟前体细胞产生自我耐受的T细胞。因此，研究调节胸腺内基质微环境建立和维持的机制对于我们理解T细胞的产生以及最终免疫系统的功能至关重要。尽管我们有能力从表型上定义胸腺的基质细胞区室，但调节它们发育的机制以及它们影响T细胞前体的方式仍不清楚。在这里，我们回顾了最近的研究发现，并强调了与胸腺基质细胞发育和功能相关的未解决问题。
