鉴定连锁不平衡程度不同区域的标签单核苷酸多态性。
Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium.
机构信息
Inherited Disease Research Branch, NHGRI/NIH, Baltimore, MD, USA.
出版信息
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S73. doi: 10.1186/1471-2156-6-S1-S73.
Abstract
We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical distance. We used the Collaborative Studies on the Genetics of Alcoholism dataset, part of the Genetic Analysis Workshop 14. We show that in regions with moderate to strong LD these programs are relatively consistent, despite different parameters and methods. In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased.
摘要
我们比较了七种不同的标签单核苷酸多态性 (SNP) 程序在 10 个具有不同程度连锁不平衡 (LD) 和物理距离的区域。我们使用了酒精中毒遗传学协作研究数据集，这是遗传分析研讨会 14 的一部分。我们表明，在中度至强 LD 区域，这些程序相对一致，尽管参数和方法不同。此外，我们还比较了一个具有强 LD 的区域的多点连锁分析中选择的 SNPs。随着所选 SNPs 数量的增加，LOD 评分、平均信息量和 I 型错误也增加。
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