大肠杆菌需要MurQ醚酶来代谢从环境或自身细胞壁获得的脱水N-乙酰胞壁酸。
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
作者信息
Uehara Tsuyoshi, Suefuji Kyoko, Jaeger Tina, Mayer Christoph, Park James T
机构信息
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
出版信息
J Bacteriol. 2006 Feb;188(4):1660-2. doi: 10.1128/JB.188.4.1660-1662.2006.
Abstract
MurQ is an N-acetylmuramic acid-phosphate (MurNAc-P) etherase that converts MurNAc-P to N-acetylglucosamine-phosphate and is essential for growth on MurNAc as the sole source of carbon (T. Jaegar, M. Arsic, and C. Mayer, J. Biol. Chem. 280:30100-30106, 2005). Here we show that MurQ is the only MurNAc-P etherase in Escherichia coli and that MurQ and AnmK kinase are required for utilization of anhydro-MurNAc derived either from cell wall murein or imported from the medium.
摘要
MurQ是一种N - 乙酰胞壁酸 - 磷酸（MurNAc - P）醚酶，可将MurNAc - P转化为N - 乙酰葡糖胺 - 磷酸，并且对于以MurNAc作为唯一碳源的生长至关重要（T. 耶格尔、M. 阿尔西克和C. 迈耶，《生物化学杂志》280:30100 - 30106，2005年）。在此我们表明，MurQ是大肠杆菌中唯一的MurNAc - P醚酶，并且MurQ和AnmK激酶是利用源自细胞壁胞壁质或从培养基中导入的脱水MurNAc所必需的。
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