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1
Interactions between inositol tris- and tetrakis-phosphates. Effects on intracellular Ca2+ mobilization in SH-SY5Y cells.肌醇三磷酸和四磷酸之间的相互作用。对SH-SY5Y细胞内钙离子动员的影响。
Biochem J. 1991 May 15;276 ( Pt 1)(Pt 1):163-7. doi: 10.1042/bj2760163.
2
Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells.肌醇-1,3,4,5-四磷酸通过肌醇-1,4,5-三磷酸受体在SH-SY5Y神经母细胞瘤细胞中诱导钙动员。
Mol Pharmacol. 1993 Oct;44(4):810-7.
3
Inositol 1,3,4,5-tetrakisphosphate-induced release of intracellular Ca2+ in SH-SY5Y neuroblastoma cells.肌醇1,3,4,5-四磷酸诱导SH-SY5Y神经母细胞瘤细胞内钙离子释放
Biochem J. 1990 Dec 1;272(2):519-24. doi: 10.1042/bj2720519.
4
Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities.肌醇1,4,5-三磷酸在C2处的修饰产生具有强大生物活性的肌醇三磷酸和四磷酸。
Eur J Biochem. 1994 Jul 1;223(1):115-24. doi: 10.1111/j.1432-1033.1994.tb18972.x.
5
Myo-inositol 1,3,4,5-tetrakisphosphate can independently mobilise intracellular calcium, via the inositol 1,4,5-trisphosphate receptor: studies with myo-inositol 1,4,5-trisphosphate-3-phosphorothioate and myo-inositol hexakisphosphate.肌醇1,3,4,5-四磷酸可通过肌醇1,4,5-三磷酸受体独立动员细胞内钙：使用肌醇1,4,5-三磷酸-3-硫代磷酸酯和肌醇六磷酸的研究。
FEBS Lett. 1993 Dec 27;336(2):267-71. doi: 10.1016/0014-5793(93)80817-e.
6
Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors.肌醇-1,3,4-三磷酸和肌醇-1,4,6-三磷酸的对映体：小脑和血小板肌醇-1,4,5-三磷酸受体的立体特异性识别
Mol Pharmacol. 1996 Nov;50(5):1223-30.
7
Inositol 1,3,4,5-tetrakisphosphate stimulates calcium release from bovine adrenal microsomes by a mechanism independent of the inositol 1,4,5-trisphosphate receptor.肌醇1,3,4,5-四磷酸通过一种独立于肌醇1,4,5-三磷酸受体的机制刺激牛肾上腺微粒体释放钙。
Biochem J. 1990 Jun 1;268(2):333-8. doi: 10.1042/bj2680333.
8
Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group.在1-磷酸基团上选择性取代的肌醇1,4,5-三磷酸光亲和类似物的合成与应用。
Biochem J. 1990 Dec 15;272(3):817-25. doi: 10.1042/bj2720817.
9
Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.肌醇 1,4,5-三磷酸受体的分子识别。3-位取代的肌醇 1,4,5-三磷酸类似物揭示了与肌醇 1,4,5-三磷酸受体高亲和力相互作用的结合和 Ca2+ 释放要求。
J Biol Chem. 1994 Oct 28;269(43):26815-21.
10
Inositol tetrakisphosphate-induced sequestration of Ca2+ replenishes an intracellular pool sensitive to inositol trisphosphate.肌醇四磷酸诱导的钙离子螯合补充了对肌醇三磷酸敏感的细胞内钙库。
J Cell Physiol. 1990 Jan;142(1):163-9. doi: 10.1002/jcp.1041420120.

引用本文的文献

1
The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells.肌醇1,3,4,5-四磷酸对新鲜分离和培养的小鼠泪腺腺泡细胞中肌醇三磷酸诱导的Ca2+动员的影响。
Biochem J. 2000 Apr 1;347 Pt 1(Pt 1):77-82.
2
Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.肌醇1,4,5-三磷酸受体亚型对D-肌醇1,4,5-三磷酸的区域异构体具有不同的识别能力。
Biochem J. 1997 Nov 15;328 ( Pt 1)(Pt 1):93-8. doi: 10.1042/bj3280093.
3
Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites.肌醇1,3,4,5 - 四磷酸对肌醇2,4,5 - 三磷酸刺激的Ca2+释放的协同作用并不涉及肌醇1,3,4,5 - 四磷酸与肌醇三磷酸结合位点的直接相互作用。
Biochem J. 1996 Mar 15;314 ( Pt 3)(Pt 3):811-6. doi: 10.1042/bj3140811.
4
Inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in smooth muscle.平滑肌中肌醇1,4,5-三磷酸和肌醇1,3,4,5-四磷酸结合位点
Br J Pharmacol. 1993 Aug;109(4):905-12. doi: 10.1111/j.1476-5381.1993.tb13706.x.
5
Stereoselectivity of Ins(1,3,4,5)P4 recognition sites: implications for the mechanism of the Ins(1,3,4,5)P4-induced Ca2+ mobilization.肌醇(1,3,4,5)四磷酸识别位点的立体选择性：对肌醇(1,3,4,5)四磷酸诱导的钙离子动员机制的影响
Biochem J. 1993 Aug 15;294 ( Pt 1)(Pt 1):191-4. doi: 10.1042/bj2940191.
6
Regulation of histamine- and UTP-induced increases in Ins(1,4,5)P3, Ins (1,3,4,5)P4 and Ca2+ by cyclic AMP in DDT1 MF-2 cells.环磷酸腺苷对DDT1 MF-2细胞中组胺和尿苷三磷酸诱导的肌醇-1,4,5-三磷酸、肌醇-1,3,4,5-四磷酸及钙离子增加的调节作用
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7
D-myo-inositol 1,3,4,5-tetrakisphosphate releases Ca2+ from crude microsomes and enriched vesicular plasma membranes, but not from intracellular stores of permeabilized T-lymphocytes and monocytes.D-肌醇1,3,4,5-四磷酸可从粗微粒体和富含小泡的质膜中释放Ca2+，但不能从透化的T淋巴细胞和单核细胞的细胞内储存库中释放。
Biochem J. 1992 Dec 1;288 ( Pt 2)(Pt 2):489-95. doi: 10.1042/bj2880489.
8
Elevation of cytosolic calcium by cholinoceptor agonists in SH-SY5Y human neuroblastoma cells: estimation of the contribution of voltage-dependent currents.胆碱能受体激动剂使SH-SY5Y人神经母细胞瘤细胞胞质钙升高：电压依赖性电流贡献的评估
Br J Pharmacol. 1992 Sep;107(1):207-14. doi: 10.1111/j.1476-5381.1992.tb14488.x.

本文引用的文献

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Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.肌醇三磷酸介导促甲状腺激素释放激素对大鼠催乳素分泌垂体细胞中非线粒体钙的动员。
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2
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.D-肌醇1:2-环磷酸酯2-磷酸水解酶
Biochem J. 1972 Mar;127(1):113-8. doi: 10.1042/bj1270113.
3
Inositol phosphates. Profusion and confusion.肌醇磷酸酯。繁多与复杂。
Nature. 1986;319(6050):176-7. doi: 10.1038/319176a0.
4
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.微量注射肌醇1,3,4,5 - 四磷酸通过一种依赖于细胞外钙离子的机制激活海胆卵。
Biochem J. 1986 Dec 15;240(3):917-20. doi: 10.1042/bj2400917.
5
Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.HL-60细胞细胞膜上[3H]肌醇（1,3,4,5）四磷酸的特异性结合位点
Biochem Biophys Res Commun. 1987 Dec 16;149(2):680-5. doi: 10.1016/0006-291x(87)90421-9.
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Heterogenous inositol tetrakisphosphate binding sites in the adrenal cortex.肾上腺皮质中异质性肌醇四磷酸结合位点
J Biol Chem. 1988 Jun 15;263(17):7940-2.
7
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells.L-肌醇1,4,5,6-四磷酸存在于哺乳动物和鸟类细胞中。
Biochem J. 1988 Jan 1;249(1):271-82. doi: 10.1042/bj2490271.
8
Inositol trisphosphate and diacylglycerol: two interacting second messengers.肌醇三磷酸和二酰甘油：两种相互作用的第二信使。
Annu Rev Biochem. 1987;56:159-93. doi: 10.1146/annurev.bi.56.070187.001111.
9
Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-triphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate.肌醇1,4,5-三磷酸对细胞内Ca2+的立体特异性动员。与肌醇1,4,5-三硫代磷酸酯和肌醇1,3,4-三磷酸的比较。
Biochem J. 1988 Aug 1;253(3):901-5. doi: 10.1042/bj2530901.
10
Inositol phosphates: proliferation, metabolism and function.肌醇磷酸：增殖、代谢与功能
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肌醇三磷酸和四磷酸之间的相互作用。对SH-SY5Y细胞内钙离子动员的影响。

Interactions between inositol tris- and tetrakis-phosphates. Effects on intracellular Ca2+ mobilization in SH-SY5Y cells.

作者信息

Gawler D J, Potter B V, Gigg R, Nahorski S R

机构信息

Department of Pharmacology, University of Leicester, U.K.

出版信息

Biochem J. 1991 May 15;276 ( Pt 1)(Pt 1):163-7. doi: 10.1042/bj2760163.

DOI:10.1042/bj2760163
PMID:1645528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1151159/
Abstract

The potential Ca2(+)-releasing activity of the inositol tetrakisphosphates Ins(1,3,4,6)P4 and DL-Ins(1,4,5,6)P4 and the inositol pentakisphosphate Ins(1,3,4,5,6)P5 and their effect on Ins(1,4,5)P3- and DL-Ins (1,3,4,5)P4-mediated Ca2+ release were examined in permeabilized SH-SY5Y human neuroblastoma cells. Neither DL-Ins(1,4,5,6)P4 nor Ins(1,3,4,5,6)P5 exhibit Ca2(+)-releasing activity at concentrations up to 10 microM, but Ins(1,3,4,6)P4 releases Ca2+ dose-dependently, with an EC50 value (conen, giving half-maximal effect) of 5.92 +/- 0.47 microM. Maximal response by this tetrakisphosphate (49 +/- 2.5%) is significantly less than that seen with Ins(1,4,5)P3 (60 +/- 3%) and is achieved at a concentration of 30 microM. In the presence of this concentration of Ins(1,3,4,6)P4 the EC50 value for Ins(1,4,5)P3-mediated Ca2+ release increases from 0.12 +/- 0.02 microM to 2.11 +/- 0.51 microM, providing evidence that this naturally occurring inositol tetrakisphosphate may recognize and exhibit its Ca2(+)-releasing activity via the Ins(1,4,5)P3 receptor. DL-Ins(1,3,4,5)P4, however, at its maximally effective concentration (10 microM) does not significantly affect Ins(1,4,5)P3-mediated Ca2+ release, and therefore appears to mediate its Ca2(+)-mobilizing action through a receptor distinct from that for Ins(1,4,5)P3.

摘要

在通透的SH-SY5Y人神经母细胞瘤细胞中，检测了肌醇四磷酸Ins(1,3,4,6)P4和DL-Ins(1,4,5,6)P4以及肌醇五磷酸Ins(1,3,4,5,6)P5潜在的Ca2+释放活性，及其对Ins(1,4,5)P3和DL-Ins(1,3,4,5)P4介导的Ca2+释放的影响。在浓度高达10 microM时，DL-Ins(1,4,5,6)P4和Ins(1,3,4,5,6)P5均未表现出Ca2+释放活性，但Ins(1,3,4,6)P4呈剂量依赖性释放Ca2+，其半数有效浓度（EC50值，产生半数最大效应的浓度）为5.92±0.47 microM。这种四磷酸酯的最大反应（49±2.5%）显著低于Ins(1,4,5)P3（60±3%），且在30 microM浓度时达到最大反应。在该浓度的Ins(1,3,4,6)P4存在下，Ins(1,4,5)P3介导的Ca2+释放的EC50值从0.12±0.02 microM增加到2.11±0.51 microM，这表明这种天然存在的肌醇四磷酸可能通过Ins(1,4,5)P3受体识别并表现出其Ca2+释放活性。然而，DL-Ins(1,3,4,5)P4在其最大有效浓度（10 microM）时，对Ins(1,4,5)P介导的Ca2+释放没有显著影响，因此似乎通过一种不同于Ins(1,4,5)P3受体的受体介导其Ca2+动员作用。