通过表面活性剂去除法制备的二辛基二甲基溴化铵囊泡。

Dioctadecyldimethylammonium bromide vesicles prepared by the surfactant removal method.

作者信息

Feitosa Eloi, Karlsson Göran

机构信息

Physics Departament, Sao Paulo State University, São José do Rio Preto, SP, Brasil.

出版信息

J Colloid Interface Sci. 2006 Jun 15;298(2):1000-1. doi: 10.1016/j.jcis.2006.01.016. Epub 2006 Feb 2.

DOI:10.1016/j.jcis.2006.01.016

PMID:16457833

Abstract

Dioctadecyldimethylammonium bromide (DODAB) is a double chain vesicle-forming cationic surfactant, whereas octa-ethyleneglycol mono-n-dodecyl ether (C12E8) is a single chain micelle-forming nonionic surfactant. At room temperature (ca. 22 degrees C) C12E8 molecules self-assemble in water as micelles while DODAB is insoluble. A mixture of DODAB and C12E8, however, can be soluble in water at room temperature depending on the relative amount of the compounds. We report the formation of small unilamellar vesicles (SUVs) by dialyzing at room temperature a mixture of 1.0 mM DODAB with 10 mM C12E8 in water. Extended bilayers are formed as well in equilibrium with vesicles. Such structures are viewed by a cryogenic transmission electron microscopy (cryo-TEM) image.

摘要

二辛基二甲基溴化铵（DODAB）是一种双链形成囊泡的阳离子表面活性剂，而八乙二醇单正十二烷基醚（C12E8）是一种单链形成胶束的非离子表面活性剂。在室温（约22摄氏度）下，C12E8分子在水中自组装成胶束，而DODAB不溶。然而，DODAB和C12E8的混合物在室温下能否溶于水取决于化合物的相对含量。我们报告了通过在室温下透析水中1.0 mM DODAB与10 mM C12E8的混合物形成小单层囊泡（SUV）。同时也会形成与囊泡处于平衡状态的延伸双层结构。通过低温透射电子显微镜（cryo-TEM）图像观察到了此类结构。