Vernersson Emma, Khoo Nelson K S, Henriksson Maria L, Roos Göran, Palmer Ruth H, Hallberg Bengt
Department of Medical Biosciences/Pathology, Building 6M, 2nd Floor, Umeå University, S-901 87 Umeå, Sweden.
Gene Expr Patterns. 2006 Jun;6(5):448-61. doi: 10.1016/j.modgep.2005.11.006. Epub 2006 Feb 2.
Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, was first described as the fusion product causing a subtype of non-Hodgkin's lymphoma. To date Alk has been reported to be mainly expressed in CNS and other parts of the brain. Here we describe an extensive characterization of the mRNA and protein expression of ALK during mouse development. We show that mRNA and ALK protein show overlapping expressing patterns in specific regions of the central and the peripheral nervous systems. Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary.
间变性淋巴瘤激酶（ALK）是一种受体酪氨酸激酶，最初被描述为导致非霍奇金淋巴瘤一种亚型的融合产物。迄今为止，已报道ALK主要在中枢神经系统和大脑的其他部位表达。在此，我们描述了小鼠发育过程中ALK的mRNA和蛋白质表达的广泛特征。我们表明，mRNA和ALK蛋白在中枢和外周神经系统的特定区域呈现重叠的表达模式。此外，ALK也在眼睛、鼻上皮、嗅神经、舌头、皮肤、食管、胃和中肠周围组织中表达，但在后肠中不表达。在睾丸和卵巢中也发现了ALK的表达。
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