Yazdi H M, Burns B F
Department of Laboratory Medicine, Ottawa Civic Hospital, Ontario, Canada.
Acta Cytol. 1991 May-Jun;35(3):306-10.
The cytopathologic, immunohistochemical and ultrastructural features of a case of Ki-1-positive lymphoma are presented and discussed. On fine needle aspiration (FNA) biopsy smears, the Ki-1-positive lymphoma was characterized by large isolated cells with abundant dense/vacuolated cytoplasm and large nuclei with irregular profiles. Although most cells contained one nucleus, binucleated and multilobed/multinucleated cells were also seen. The cohesion of the malignant cells in histologic sections of a biopsied lymph node suggested an anaplastic carcinoma. The discrepancy was resolved by ultrastructural and immunologic analyses. The main differential diagnoses on FNA material include Hodgkin's disease, malignant melanoma and undifferentiated carcinoma; the cytologic suspicion should be confirmed by immunocytochemical studies.
本文呈现并讨论了一例Ki-1阳性淋巴瘤的细胞病理学、免疫组织化学及超微结构特征。在细针穿刺（FNA）活检涂片上，Ki-1阳性淋巴瘤的特征为单个大细胞，胞质丰富、致密/有空泡，细胞核大且轮廓不规则。尽管大多数细胞含有一个核，但也可见双核及多叶/多核细胞。活检淋巴结组织切片中恶性细胞的黏附性提示为间变性癌。通过超微结构和免疫分析解决了这一差异。FNA材料的主要鉴别诊断包括霍奇金病、恶性黑色素瘤和未分化癌；细胞学怀疑应通过免疫细胞化学研究来证实。
