Kobayashi Yasuhiro, Takahashi Naoyuki
Institute for Oral Science, Matsumoto Dental University.
Clin Calcium. 2006 Feb;16(2):311-18.
Osteoporosis is a systemic skeletal disease characterized by low bone mass and the microarchitectural deterioration of bone tissue. The pathophysiology of osteoporosis is complex, involving a broad spectrum of endogenous and environmental factors. Recently, molecular and genetic approaches are revealing that genetic backgrounds are important for the pathophysiology of osteoporosis. We discuss about recent findings of osteoporosis and osteopenia caused by monogenic mutations in humans and mice.
骨质疏松症是一种全身性骨骼疾病，其特征为骨量低和骨组织微结构破坏。骨质疏松症的病理生理学很复杂，涉及多种内源性和环境因素。最近，分子和遗传学方法表明，遗传背景对骨质疏松症的病理生理学很重要。我们讨论了人类和小鼠单基因突所导致的骨质疏松症和骨质减少的最新研究发现。
