由丙酮酸盐和过一硫酸氢钾复合盐原位生成的二氧杂环丙烷作为环境友好型消毒剂的氧化剂。

Dioxiranes generated in situ from pyruvates and oxone as environmentally friendly oxidizing agents for disinfection.

作者信息

Wong Man-Kin, Chan Tak-Chung, Chan Wai-Yee, Chan Wing-Kei, Vrijmoed Lilian L P, O'Toole Desmond K, Che Chi-Ming

机构信息

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, China.

出版信息

Environ Sci Technol. 2006 Jan 15;40(2):625-30. doi: 10.1021/es050688l.

DOI:10.1021/es050688l

PMID:16468412

Abstract

Dioxiranes generated in situ from pyruvates (alpha-keto esters) and Oxone have been found to be environmentally friendly oxidizing agents for disinfection. These oxidizing agents were highly effective for destruction of various strains of bacteria, fungi, and bacterial endospores in a wide temperature range with exceptional stability. Notably, by using an aqueous solution of methyl pyruvate (1a) and Oxone/NaHCO3, complete destruction of bacteria such as Staphylococcus aureus and fungus Penicillium corylophilum was achieved within 5 min at 20 degrees C at neutral pH. Highly chemical-resistant bacterial endospores of Bacillus cereus could also be destroyed. The high antibacterial activity of 1a could be attributed to its strong electron-withdrawing alpha-ester group.

摘要

已发现由丙酮酸（α-酮酯）和过硫酸氢钾复合盐原位生成的二氧杂环丙烷是用于消毒的环境友好型氧化剂。这些氧化剂在很宽的温度范围内对各种细菌、真菌和细菌芽孢具有高效的破坏作用，且稳定性极佳。值得注意的是，通过使用丙酮酸甲酯（1a）与过硫酸氢钾复合盐/碳酸氢钠的水溶液，在20℃、中性pH条件下，5分钟内就能完全杀灭金黄色葡萄球菌等细菌以及嗜榛青霉等真菌。蜡样芽孢杆菌的高度耐化学性细菌芽孢也能被破坏。1a的高抗菌活性可归因于其强吸电子的α-酯基。