一种采用持续低剂量炔雌醇的延长疗程口服避孕药的安全性与有效性。
Safety and efficacy of an extended-regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol.
作者信息
Anderson Freedolph D, Gibbons William, Portman David
机构信息
The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23507-1627, USA.
出版信息
Contraception. 2006 Mar;73(3):229-34. doi: 10.1016/j.contraception.2005.09.010. Epub 2005 Nov 2.
OBJECTIVE
To assess the efficacy and safety of Seasonique, a 91-day extended-regimen oral contraceptive (OC) utilizing continuous low-dose ethinyl estradiol (EE) during the typical hormone-free interval.
METHODS
A multicenter, open-label, 1-year study of Seasonique [30 microg EE/150 microg levonorgestrel (LNG)] for 84 days followed by EE 10 microg for 7 days was conducted in sexually active, adult women of childbearing potential. All patients completed daily electronic diaries to monitor compliance and bleeding.
RESULTS
Method failure rate was 0.78 (Pearl index) and 0.64% (life table analysis). Cycle control and safety of the regimen were similar to that reported for other OCs.
CONCLUSION
This study demonstrates that Seasonique is effective, safe and well tolerated for the prevention of pregnancy.
目的
评估Seasonique（一种91天延长疗程的口服避孕药，在典型的无激素间隔期使用持续低剂量乙炔雌二醇（EE））的有效性和安全性。
方法
对有生育潜力的性活跃成年女性进行了一项为期1年的多中心、开放标签研究，研究对象服用Seasonique[30微克EE/150微克左炔诺孕酮（LNG）]84天，随后服用7天10微克EE。所有患者完成每日电子日记以监测依从性和出血情况。
结果
方法失败率为0.78（ Pearl指数）和0.64%（生命表分析）。该疗程的周期控制和安全性与其他口服避孕药报道的相似。
结论
本研究表明，Seasonique在预防妊娠方面有效、安全且耐受性良好。
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