肉毒杆菌毒素胃窦注射对肥胖患者胃排空及体重减轻的影响：一项初步研究。
Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study.
作者信息
Gui D, Mingrone G, Valenza V, Spada P L, Mutignani M, Runfola M, Scarfone A, Di Mugno M, Panunzi S
机构信息
Department of Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Aliment Pharmacol Ther. 2006 Mar 1;23(5):675-80. doi: 10.1111/j.1365-2036.2006.02773.x.
BACKGROUND
A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility.
AIM
To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying.
METHODS
In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx-A133U, Btx-A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks.
RESULTS
Fourteen patients completed the study. The botulinum toxin A-treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite.
CONCLUSION
This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.
背景
治疗病态肥胖的一种潜在方法是减缓胃排空以实现饱腹感。肉毒杆菌毒素A（Btx-A）是乙酰胆碱介导的蠕动的长效抑制剂，而乙酰胆碱介导的蠕动主要负责胃的运动。
目的
研究向肥胖患者胃窦注射肉毒杆菌毒素A是否会延迟胃排空。
方法
在一项双盲研究中，18名健康肥胖受试者（体重指数>30）被随机分为三组（BTX133、BTX200和生理盐水组）；在内镜控制下，他们分别接受133U Btx-A、200U Btx-A或生理盐水注射。在治疗前和治疗后10天通过闪烁扫描法检测胃排空情况。5周后记录体重变化和食欲感觉。
结果
14名患者完成了研究。肉毒杆菌毒素A治疗组体重减轻，但无统计学意义。对胃排空的影响各不相同。大多数接受肉毒杆菌毒素A治疗的患者报告食欲下降。
结论
这项初步临床试验表明肉毒杆菌毒素A在控制食欲方面具有潜在活性。
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