Ruchholtz S, Pehle B, Lewan U, Lefering R, Müller N, Oberbeck R, Waydhas C
Department of Trauma Surgery, University Hospital, Essen, Germany.
Transfus Med. 2006 Feb;16(1):49-56. doi: 10.1111/j.1365-3148.2006.00647.x.
The presented study was initiated to develop a scoring system for the prediction of red blood cell transfusion requirement in the early care of trauma patients. All trauma patients admitted to our institution who needed trauma team activation were evaluated during a 4-year period. A set of nine parameters with possible predictive value for the need of blood transfusion was recorded. All relevant data can be acquired during the first 10 min in the emergency room (ER). The data underwent multivariate logistic regression analysis for correlation and the calculation of predictive power. To transform the model into a practical score, we rounded all coefficients. The predictive power of the score was evaluated based on a linear regression equation. Of the 1103 patients (Injury Severity Score [ISS] 21 +/- 16) included in the study, 116 (10.5%; ISS 39 +/- 18) received blood in the ER. Early transfusion need was significantly correlated with systolic blood pressure (SBP) <90 mmHg (coefficient 2.5), SBP 90-120 mmHg (1.5), free fluid in abdominal ultrasound (2.0), clinically unstable pelvic ring fracture (1.5), age 20-60 years (0.5), age >60 years (1.5), admission from scene (1.0), traffic accident (1.0) and fall from >3 m (1.0). The probability for transfusion exponentially increased with the sum of points in the ER transfusion score, i.e. from 0.7% at one point to 5% at three points and 97% at 9.5 points maximum. To establish a practical cutoff point (risk <5%) a low-risk group was defined at <points (64% of the whole study group). The presented ER transfusion score is based on rapidly assessable parameters. The score identifies patients in need for immediate red blood cell substitution. Cost effectiveness appears to be a further advantage of the score. For patients not in need of urgent transfusion (low-risk group), the costs for transportation, cross-matching and loss by maltreatment of blood products may be avoided.
本研究旨在开发一种评分系统,用于预测创伤患者早期治疗中红细胞输注需求。在4年期间,对我院所有需要启动创伤团队的创伤患者进行了评估。记录了一组9个可能对输血需求具有预测价值的参数。所有相关数据均可在急诊室(ER)的前10分钟内获取。对数据进行多因素逻辑回归分析以确定相关性并计算预测能力。为了将模型转化为实用评分,我们对所有系数进行了四舍五入。基于线性回归方程评估评分的预测能力。在纳入研究的1103例患者(损伤严重度评分[ISS]为21±16)中,116例(10.5%;ISS为39±18)在急诊室接受了输血。早期输血需求与收缩压(SBP)<90 mmHg(系数2.5)、SBP 90 - 120 mmHg(1.5)、腹部超声显示游离液体(2.0)、临床不稳定骨盆环骨折(1.5)、年龄20 - 60岁(0.5)、年龄>60岁(1.5)、现场入院(1.0)、交通事故(1.0)以及从>3米高处坠落(1.0)显著相关。输血概率随急诊室输血评分的总分呈指数增加,即从1分的0.7%增加到3分的5%,最高可达9.5分的97%。为确定一个实用的临界点(风险<5%),将<6分的患者定义为低风险组(占整个研究组的64%)。所提出的急诊室输血评分基于可快速评估的参数。该评分可识别需要立即进行红细胞替代的患者。成本效益似乎是该评分的另一个优势。对于不需要紧急输血的患者(低风险组),可避免运输、交叉配血以及血液制品不当处理造成的损失等费用。