胃癌中的E-钙黏蛋白
E-cadherin in gastric cancer.
作者信息
Chan Annie On On
机构信息
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
出版信息
World J Gastroenterol. 2006 Jan 14;12(2):199-203. doi: 10.3748/wjg.v12.i2.199.
Abstract
Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.
摘要
钙黏蛋白是一种黏附分子，是钙介导的膜糖蛋白超家族。E-钙黏蛋白是E-钙黏蛋白家族的原型，它与连环蛋白相连形成细胞骨架。最近的证据表明，E-钙黏蛋白不仅作为一种黏附分子起作用，而且在生长发育和致癌过程中也发挥重要作用。它最近被视为一种侵袭抑制基因和生长抑制基因。本文综述了关于E-钙黏蛋白及其在胃癌中作用的最新发现。特别是，我们对胃癌中E-钙黏蛋白的研究工作，包括其与幽门螺杆菌的关系及临床应用，将详细阐述。
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