Mayer S, Brüderlein S, Perner S, Waibel I, Holdenried A, Ciloglu N, Hasel C, Mattfeldt T, Nielsen K V, Möller P
Institute of Pathology, University of Ulm, Ulm, Germany.
Cytogenet Genome Res. 2006;112(3-4):194-201. doi: 10.1159/000089870.
During aging, telomeres are gradually shortened, eventually leading to cellular senescence. By T/C-FISH (telomere/centromere-FISH), we investigated human telomere length differences on single chromosome arms of 205 individuals in different age groups and sexes. For all chromosome arms, we found a linear correlation between telomere length and donor age. Generally, males had shorter telomeres and higher attrition rates. Every chromosome arm had its individual age-specific telomere length and erosion pattern, resulting in an unexpected heterogeneity in chromosome-specific regression lines. This differential erosion pattern, however, does not seem to be accidental, since we found a correlation between average telomere length of single chromosome arms in newborns and their annual attrition rate. Apart from the above-mentioned sex-specific discrepancies, chromosome arm-specific telomere lengths were strikingly similar in men and women. This implies a mechanism that arm specifically regulates the telomere length independent of gender, thus leading to interchromosomal telomere variations.
在衰老过程中，端粒会逐渐缩短，最终导致细胞衰老。通过端粒/着丝粒荧光原位杂交技术（T/C-FISH），我们研究了205名不同年龄组和性别的个体在单条染色体臂上的人类端粒长度差异。对于所有染色体臂，我们发现端粒长度与供体年龄之间存在线性相关性。一般来说，男性的端粒较短且损耗率较高。每条染色体臂都有其特定年龄的端粒长度和侵蚀模式，导致染色体特异性回归线出现意想不到的异质性。然而，这种差异侵蚀模式似乎并非偶然，因为我们发现新生儿单条染色体臂的平均端粒长度与其年损耗率之间存在相关性。除了上述性别特异性差异外，男性和女性染色体臂特异性端粒长度惊人地相似。这意味着存在一种机制，即染色体臂特异性地调节端粒长度，而与性别无关，从而导致染色体间端粒变异。
