Bracesco Nelson, Salvo Virgilio A, Carrau Francisco M, Nunes Elia
Lab. Radiobiología. Dpt. Biofísica. Facultades de Medicina y Ciencias, Univ. de la República Uruguay.
FEMS Microbiol Lett. 2006 Mar;256(1):132-6. doi: 10.1111/j.1574-6968.2006.00113.x.
It is known that certain yeast strains, so called 'killers', can produce and excrete proteinaceous toxins that can induce death of other sensitive strains. We obtained a stable fungicidal factor (SKF) through concentration and stabilization of the excretion product of certain killer strains of Saccharomyces cerevisiae (K1 and K2). The isolated proteinaceous complex exhibited activity at broad ranges of pH (4-7.5) and temperatures (20-37.5 degrees C). It was significantly lethal against Candida albicans and Tricophyton mentagrophytes. SKF showed stability and activity after storage, with a mean half-life of 6 months at 4 degrees C or at -20 degrees C.
已知某些酵母菌株，即所谓的“杀手”菌株，能够产生并分泌蛋白质毒素，这些毒素可导致其他敏感菌株死亡。我们通过浓缩和稳定酿酒酵母某些杀手菌株（K1和K2）的排泄产物，获得了一种稳定的杀真菌因子（SKF）。分离出的蛋白质复合物在广泛的pH范围（4 - 7.5）和温度范围（20 - 37.5摄氏度）内均表现出活性。它对白色念珠菌和须癣毛癣菌具有显著的致死性。SKF在储存后仍保持稳定性和活性，在4摄氏度或 - 20摄氏度下平均半衰期为6个月。
