Zhang Jianyu, Russo Gary S, Mewes Klaus, Rye David B, Vitek Jerrold L
Center for Neurological Restoration, Cleveland Clinic Foundation, 9500 Euclid Avenue, S31, Cleveland, OH 44195, USA.
Exp Neurol. 2006 Jun;199(2):446-53. doi: 10.1016/j.expneurol.2006.01.006. Epub 2006 Feb 17.
To further define the role of the external segment of the globus pallidus (GPe) in the development of parkinsonian motor signs, two rhesus monkeys were made parkinsonian with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behavioral assessments of bradykinesia and akinesia as well as single neuron recordings in the internal segment of the globus pallidus (GPi) were performed in both monkeys before and after ablating the sensorimotor portion of GPe. The effects of apomorphine on behavior and neuronal activity were also assessed in the parkinsonian monkeys before and after GPe ablation. We found that lesions in GPe exacerbated parkinsonian symptoms, altered neuronal activity in GPi, and reduced the therapeutic effects of apomorphine. These results support the hypothesis that GPe can influence GPi neuronal activity and is directly involved in parkinsonism. In addition, these data suggest that the inclusion of GPe in pallidotomy lesions for the treatment of Parkinson's disease can block the beneficial effects of antiparkinsonian medications and should be avoided.
为了进一步明确苍白球外侧段（GPe）在帕金森运动症状发展中的作用，对两只恒河猴注射神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）使其患帕金森病。在切除GPe的感觉运动部分之前和之后，对两只猴子进行了运动迟缓与运动不能的行为评估以及苍白球内侧段（GPi）的单神经元记录。还在GPe切除前后对帕金森病猴子评估了阿扑吗啡对行为和神经元活动的影响。我们发现，GPe损伤加剧了帕金森病症状，改变了GPi中的神经元活动，并降低了阿扑吗啡的治疗效果。这些结果支持以下假设：GPe可影响GPi神经元活动并直接参与帕金森病。此外，这些数据表明，在用于治疗帕金森病的苍白球切开术中纳入GPe会阻碍抗帕金森药物的有益作用，应予以避免。
