McCarter Linda L
Microbiology Department, The University of Iowa, Iowa City, IA 52242, USA.
Curr Opin Microbiol. 2006 Apr;9(2):180-6. doi: 10.1016/j.mib.2006.02.001. Epub 2006 Feb 17.
Flagellar gene networks are fascinating, owing to their complexity - they usually coordinate the expression of more than 40 genes - and particular wiring that elicits temporal expression coupled to organelle morphogenesis. Moreover, many of the lessons learned from flagellar regulation are generally applicable to type III secretion systems. Our understanding of flagellar networks is rapidly expanding to include diverse organisms, as well as deepening to enable the development of predictive wiring diagrams. Numerous regulators control the regulation of flagella, and one of the next challenges in the field is to integrate flagellar gene control into master blueprints of global gene expression.
鞭毛基因网络因其复杂性而引人入胜——它们通常协调40多个基因的表达——以及引发与细胞器形态发生相关的时间表达的特定线路。此外,从鞭毛调节中学到的许多经验教训通常适用于III型分泌系统。我们对鞭毛网络的理解正在迅速扩展,涵盖多种生物体,同时也在不断深入,以绘制出预测性的线路图。众多调节因子控制着鞭毛的调控,该领域接下来的挑战之一是将鞭毛基因控制整合到全球基因表达的总体蓝图中。