在单纯疱疹病毒（HSV）免疫供者中，针对HSV抗原的强烈供者单核细胞反应性与受者对HSV的血清学阳性相结合，与急性移植物抗宿主病相关。

Strong donor mononuclear cell reactivity for herpes simplex virus (HSV) antigen in HSV immune donors combined with recipient seropositivity for HSV is associated with acute graft-versus-host disease.

作者信息

Boström L, Ringdén O, Forsgren M

机构信息

Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.

出版信息

Scand J Immunol. 1991 Jul;34(1):45-52. doi: 10.1111/j.1365-3083.1991.tb01519.x.

DOI:10.1111/j.1365-3083.1991.tb01519.x

PMID:1648786

Abstract

Prior to bone marrow transplantation (BMT) titres of IgG antibodies for cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella zoster virus (VZV) were analysed in 51 donors and recipients of allogeneic bone marrow. Donor mononuclear cells from peripheral blood and bone marrow cells were stimulated with antigen prepared from CMV, HSV and VZV. High IgG titres for HSV in the recipient were associated with grade II-III acute graft-versus-host disease (GVHD) (P = 0.05). Furthermore, the combination of positive IgG titre for HSV antibodies in the recipient, and strong donor blood mononuclear cell reactivity to HSV antigen in HSV immune donors, significantly increased the incidence of grade II-III acute GVHD (P = 0.04). The data suggest that HSV immune donor mononuclear cells may initiate a GVH reaction.

摘要

在进行异基因骨髓移植前，对51例异基因骨髓供体和受体的巨细胞病毒（CMV）、单纯疱疹病毒（HSV）和水痘-带状疱疹病毒（VZV）的IgG抗体滴度进行了分析。用CMV、HSV和VZV制备的抗原刺激外周血中的供体单核细胞和骨髓细胞。受体中HSV的高IgG滴度与II-III级急性移植物抗宿主病（GVHD）相关（P = 0.05）。此外，受体中HSV抗体的IgG滴度呈阳性，且HSV免疫供体的供体血单核细胞对HSV抗原具有强烈反应性，这显著增加了II-III级急性GVHD的发生率（P = 0.04）。数据表明，HSV免疫供体单核细胞可能引发GVH反应。