Jonas J B, Back W, Sauder G, Jünemann U, Harder B, Spandau U H
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.
Eur J Ophthalmol. 2006 Jan-Feb;16(1):171-2.
To report on the occurrence of histology-proven sympathetic ophthalmia in a patient with VATER association and persisting hyperplastic primary vitreous (PHPV) after a cyclodestructive procedure was performed to treat secondary angle-closure glaucoma.
The left eye of a 13-year-old boy with VATER association was microphthalmic from birth and had been diagnosed with PHPV at age 1 year. It developed iris neovascularization and secondary angle-closure glaucoma, which was treated by combined cyclocryocoagulation and cyclophotocoagulation. Six weeks later, a bilateral fibrinous iritis developed. Despite intensive topical and systemic steroid treatment, the iritis persisted so that the left blind eye was enucleated.
Histology of the enucleated eye showed a marked intraocular inflammation with lymphocytes, epithelioid cells, and multinuclear giant cells grouped around remnants of melanin-bearing cells.
Sympathetic ophthalmia may occur in patients with VATER association and PHPV after a secondary angle-closure glaucoma is treated by a combined cyclocryocoagulation and cyclophotocoagulation.
报告1例患有VATER综合征及永存性增生性原始玻璃体（PHPV）的患者，在接受睫状体破坏术治疗继发性闭角型青光眼后发生经组织学证实的交感性眼炎。
一名患有VATER综合征的13岁男孩，左眼自出生起即为小眼球，1岁时被诊断为PHPV。该眼出现虹膜新生血管及继发性闭角型青光眼，接受了睫状体冷凝术联合睫状体光凝术治疗。六周后，双侧发生纤维素性虹膜炎。尽管进行了强化局部及全身类固醇治疗，虹膜炎仍持续存在，因此摘除了左侧盲眼。
摘除眼球的组织学检查显示眼内有明显炎症，淋巴细胞、上皮样细胞和多核巨细胞围绕含黑色素细胞的残余物聚集。
对于患有VATER综合征及PHPV的患者，在通过睫状体冷凝术联合睫状体光凝术治疗继发性闭角型青光眼后，可能发生交感性眼炎。
