Shen Bing, El-Dahr Samir S
Tulane University Health Sciences Center, Department of Pediatrics, Section of Pediatric Nephrology, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Biol Chem. 2006 Feb;387(2):145-50. doi: 10.1515/BC.2006.019.
The renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems play a key role in multiple physiological and pathophysiological conditions, including growth and development, inflammation, blood pressure regulation and control of renal function. In many instances, kinins and angiotensin II work together, e.g., during development, whereas they oppose each other's actions in the regulation of vascular tone and renal function. The RAS and KKS systems also interact at multiple levels, so that changes in the activity of one system greatly impact the activity of the other. The purpose of this brief review is to highlight recent knowledge regarding interactions at the cellular and molecular levels between the two systems, with an emphasis on the coordinate developmental regulation of these phylogenetically conserved vasoactive systems.
肾素-血管紧张素（RAS）系统和激肽释放酶-激肽（KKS）系统在多种生理和病理生理状况中发挥关键作用，包括生长发育、炎症、血压调节以及肾功能控制。在许多情况下，激肽和血管紧张素II协同作用，例如在发育过程中，而在血管张力调节和肾功能调节方面它们的作用相互拮抗。RAS系统和KKS系统也在多个层面相互作用，以至于一个系统活性的变化会极大地影响另一个系统的活性。本简要综述的目的是强调关于这两个系统在细胞和分子水平相互作用的最新知识，重点是这些系统发育上保守的血管活性系统的协同发育调节。
