Lansac Emmanuel, Di Centa Isabelle, Bonnet Nicolas, Leprince Pascal, Rama Akthar, Acar Christophe, Pavie Alain, Gandjbakhch Iradj
Department of Cardiovascular and Thoracic Surgery, Pitie Salpetriere University Hospital, Assistance Publique Hopitaux de Paris (APHP), Institut de Cardiologie, 47-83 Boulevard de l'Hopital, 75013 Paris Cedex, France.
Eur J Cardiothorac Surg. 2006 Apr;29(4):537-44. doi: 10.1016/j.ejcts.2005.12.055. Epub 2006 Feb 24.
Dilation of aortic annulus, sinuses of Valsalva, and sinotubular junction (STJ) diameters are the characteristic lesions of aortic root aneurysm. The remodeling technique reduces STJ diameter and creates three neosinuses of Valsalva. Alternatively, the reimplantation technique reduces both annulus and STJ diameters to the detriment of aortic root dynamics. Although the remodeling technique is recognized as the most physiological valve-sparing procedure, aortic annulus dilation may jeopardize its results. A standardized approach that combines an external subvalvular aortic prosthetic ring annuloplasty with the remodeling technique is suggested.
Eighty-three patients underwent an elective aortic root remodeling procedure, either isolated (group 1, n=34) or combined with an external subvalvular aortic prosthetic ring annuloplasty (group 2, n=49). Preoperative aortic regurgitation was 1.59+/-1.1 (group 1) and 1.97+/-1.3 (group 2) (NS). The aortic annulus was more dilated in group 2 than in group 1 (27+/-2.77 mm vs 26.4+/-2.3 mm, p<0.01). Residual aortic regurgitation > or =grade II was the conversion criteria for aortic valve replacement.
Operative mortality was 3.6% (n=3). Intraoperative conversion for valve replacement was 32.7% in group 1 (n=11) versus 4.2% in group 2 (n=2) (p<0.001). In group 1, preoperative annulus diameter was larger for converted than for valve-spared patients (27.6+/-1.7 mm vs 25.2+/-1.5 mm, p<0.02). In group 2, implanted aortic ring significantly reduced annulus diameter (20.6+/-1.8 mm) without significant aortic valve gradient (8.3+/-3 mmHg). Follow-up was 17.2+/-13.4 months (group 1) and 10.41+/-7.95 months (group 2). Reoperation for recurrent aortic regurgitation was 13% in group 1 (n=3) versus 4.2% in group 2 (n=2). Echocardiographic follow-up found residual aortic regurgitation < or =grade I in 17 patients in group 1 (90%) versus 43 patients in group 2 (95.5%) and of grade II in two patients in group 1 (10%) and two patients in group 2 (4.5%).
The addition of external aortic prosthetic ring annuloplasty improves the remodeling technique's operative reproducibility and short-term results. Therefore, its use as a systematical adjunct to the remodeling procedure is suggested. However, further long-term evaluation comparing this valve-sparing procedure to composite graft replacement should define the best surgical strategy for aortic root aneurysm.
主动脉瓣环扩张、主动脉窦及窦管交界(STJ)直径增宽是主动脉根部瘤的特征性病变。重塑技术可减小STJ直径并形成三个新的主动脉窦。另外,再植技术可减小瓣环和STJ直径,但会损害主动脉根部动力学。尽管重塑技术被认为是最符合生理的保留瓣膜手术,但主动脉瓣环扩张可能会影响其效果。建议采用一种将外部瓣下主动脉人工环瓣环成形术与重塑技术相结合的标准化方法。
83例患者接受了择期主动脉根部重塑手术,其中单纯手术(第1组,n = 34)或联合外部瓣下主动脉人工环瓣环成形术(第2组,n = 49)。术前主动脉反流情况为第1组1.59±1.1,第2组1.97±1.3(无显著性差异)。第2组的主动脉瓣环比第1组更扩张(27±2.77mm对26.4±2.3mm,p<0.01)。残余主动脉反流≥Ⅱ级是主动脉瓣置换的转换标准。
手术死亡率为3.6%(n = 3)。第1组术中转为瓣膜置换的比例为32.7%(n = 11),第2组为4.2%(n = 2)(p<0.001)。在第1组中,转为瓣膜置换的患者术前瓣环直径大于保留瓣膜的患者(27.6±1.7mm对25.2±1.5mm,p<0.02)。在第2组中,植入的主动脉环显著减小了瓣环直径(20.6±1.8mm),且主动脉瓣压差无显著性差异(8. ±3mmHg)。随访时间第1组为17.2±13.4个月,第2组为10.41±7.95个月。第1组因复发性主动脉反流再次手术的比例为13%(n = 3),第2组为4.2%(n = 2)。超声心动图随访发现,第1组17例患者(90%)残余主动脉反流≤Ⅰ级,43例患者(95.5%)残余主动脉反流≤Ⅰ级;第1组2例患者(10%)残余主动脉反流为Ⅱ级,第2组2例患者(4.5%)残余主动脉反流为Ⅱ级。
增加外部主动脉人工环瓣环成形术可提高重塑技术的手术可重复性和短期效果。因此,建议将其作为重塑手术的系统性辅助手段。然而,将这种保留瓣膜手术与复合移植物置换进行进一步的长期评估,应能确定主动脉根部瘤的最佳手术策略。