Poznanovic Sheri A, Cass Stephen P, Kavanagh Brian D
Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, 4200 E. 9th Avenue, Box B-205, Denver, CO 80262, USA.
Otolaryngol Head Neck Surg. 2006 Mar;134(3):437-42. doi: 10.1016/j.otohns.2005.10.040.
Glomus jugulare tumors (GJT) have traditionally been treated by surgery or fractionated external beam radiation therapy (XRT). This study evaluates acute toxicity and short-term efficacy of single-fraction stereotactic radiosurgery (SRS) for the treatment of GJT.
Eight patients (age range 28-74) with GJT underwent SRS (Brainlab linear accelerator) as primary treatment. A nominal dose of 15-16 Gy was prescribed.
After undergoing SRS, 7 of 8 patients (87.5%) reported complete resolution of presenting symptoms. Follow-up MRIs showed tumor stabilization in 100% of patients. Transient vertigo occurred in one patient. One patient suffered acute GI upset and transient lower cranial neuropathy.
Stereotactic radiosurgery is an effective alternative for patients with GJT in achieving tumor control and resolution of symptoms.
C-4.
传统上，颈静脉球瘤（GJT）采用手术或分次外照射放疗（XRT）进行治疗。本研究评估单次立体定向放射外科治疗（SRS）颈静脉球瘤的急性毒性和短期疗效。
8例（年龄范围28 - 74岁）颈静脉球瘤患者接受SRS（Brainlab直线加速器）作为主要治疗方法。规定的名义剂量为15 - 16 Gy。
接受SRS治疗后，8例患者中有7例（87.5%）报告现有症状完全缓解。随访磁共振成像显示100%的患者肿瘤稳定。1例患者出现短暂性眩晕。1例患者出现急性胃肠道不适和短暂性下颅神经病变。
立体定向放射外科是颈静脉球瘤患者实现肿瘤控制和症状缓解的一种有效替代方法。
C - 4
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