传染性单核细胞增多症与多发性硬化症风险：一项荟萃分析。
Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis.
作者信息
Thacker Evan L, Mirzaei Fariba, Ascherio Alberto
机构信息
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Ann Neurol. 2006 Mar;59(3):499-503. doi: 10.1002/ana.20820.
OBJECTIVE
To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS).
METHODS
We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS.
RESULTS
The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.
INTERPRETATION
We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.
目的
明确传染性单核细胞增多症（IM）（儿童期后原发性EB病毒感染的常见临床表现）与多发性硬化症（MS）风险之间的关联。
方法
我们对IM与MS的病例对照研究和队列研究进行了系统评价和荟萃分析。
结果
14项研究中IM后发生MS的合并相对风险为2.3（95%置信区间，1.7 - 3.0；p < 10⁻⁸）。异质性的潜在来源（即研究设计、MS定义和纬度）对我们的结果几乎没有影响。
解读
我们得出结论，在青少年和年轻人中表现为IM的EB病毒感染是MS的一个风险因素。
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