Kim Byung Kook, Kim Mi Jin, Chang Won Chul, Yoo Kwang Ha, Shin Young Goo, Chung Choon Hee
Department of Internal Medicine, Konkuk University, Seoul, Korea.
Yonsei Med J. 2006 Feb 28;47(1):144-7. doi: 10.3349/ymj.2006.47.1.144.
Hyperlipidemia is a rare cause of pancreatitis. It has been believed that free fatty acids released from hydrolyzed serum chylomicrons or triglycerides and chylomicrons induce hyperlipidemic pancreatitis by damaging acinar cells and capillaries. Type I, IV or V hyperlipidemic (Fredrickson's classification) pancreatitides have distinctive features of increased and heightened serum chylomicron and triglyceride levels. In contrast, type IIb hyperlipidemia usually doesn't have increased chylomicrons. It is a dominant inherited genetic disorder and doesn't manifest the subjective symptom before combining vascular complications such as coronary artery disease. Only a few cases of type IIb hyperlipidemic pancreatitis have been reported. We experienced a male patient with recurrent hyperlipidemic pancreatitis combined with type IIb hyperlipidemia. We present the case report and a review of the literature of hyperlipidemic pancreatitis, especially cases in Korea.
高脂血症是胰腺炎的罕见病因。人们认为,从水解的血清乳糜微粒或甘油三酯及乳糜微粒中释放的游离脂肪酸通过损伤腺泡细胞和毛细血管而诱发高脂血症性胰腺炎。I型、IV型或V型高脂血症(弗雷德里克森分类法)胰腺炎具有血清乳糜微粒和甘油三酯水平升高且增高的独特特征。相比之下,IIb型高脂血症通常不存在乳糜微粒增加的情况。它是一种显性遗传性疾病,在合并诸如冠心病等血管并发症之前不会出现主观症状。仅报道过少数几例IIb型高脂血症性胰腺炎病例。我们诊治了一名患有复发性高脂血症性胰腺炎并合并IIb型高脂血症的男性患者。我们呈现此病例报告并对高脂血症性胰腺炎的文献进行综述,尤其是韩国的病例。