Avilés-Santa Larissa, Salinas Karin, Adams-Huet Beverley, Raskin Philip
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX 75390-8858, USA.
J Diabetes Complications. 2006 Mar-Apr;20(2):69-74. doi: 10.1016/j.jdiacomp.2005.09.001.
The purpose of this study is to compare score systems used to estimate the risk for cardiovascular disease (CVD) in young patients with poorly controlled type 2 diabetes.
Fifty-seven Latin American patients with type 2 diabetes, between the ages 18 and 45 years, were screened to participate in a clinical research study evaluating the effects of intensive insulin therapy on both traditional and nontraditional CVD risk factors. All women were premenopausal and had regular menstrual periods. Baseline reviews of cardiovascular (CV) risk scores, personal history, physical examination, and laboratory screening were performed. The Framingham Study Score system and the presence of features of the metabolic syndrome (MSyn) were recorded and compared.
Both genders had a comparable number of features of the MSyn, whereas according to the Framingham Score System, men had a slightly higher risk of CVD.
The Framingham Score system is not an accurate device to estimate risk of CVD in premenopausal women with type 2 diabetes mellitus, who otherwise have a multiple features of the MSyn. If used to estimate risk of CVD, the Framingham score system could underestimate the risk of CVD in both young men and women with type 2 diabetes mellitus.
本研究旨在比较用于评估血糖控制不佳的年轻2型糖尿病患者心血管疾病（CVD）风险的评分系统。
筛选了57名年龄在18至45岁之间的拉丁美洲2型糖尿病患者，参与一项评估强化胰岛素治疗对传统和非传统CVD危险因素影响的临床研究。所有女性均处于绝经前且月经周期规律。对心血管（CV）风险评分、个人病史、体格检查和实验室筛查进行了基线评估。记录并比较了弗雷明汉研究评分系统和代谢综合征（MSyn）特征的存在情况。
男性和女性具有可比数量的MSyn特征，而根据弗雷明汉评分系统，男性患CVD的风险略高。
弗雷明汉评分系统并非准确评估绝经前2型糖尿病女性CVD风险的工具，这些女性具有多种MSyn特征。若用于评估CVD风险，弗雷明汉评分系统可能会低估年轻男性和女性2型糖尿病患者的CVD风险。
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