新生蜗牛蛋白LAPS与经验丰富的C/EBP：长期易化作用的净转录过程
Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation.
作者信息
Eckel-Mahan Kristin L, Storm Daniel R
机构信息
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
出版信息
Neuron. 2006 Mar 2;49(5):645-6. doi: 10.1016/j.neuron.2006.02.009.
PMID:16504938
Abstract
Long-term changes in synaptic plasticity require new protein synthesis. This preview discusses data from Kim et al. (this issues of Neuron) that demonstrate the requirement of a novel, nucleolar protein, LLP (LAPS18-like protein), for the formation of long-term facilitation in Aplysia. LLP binds to and transcriptionally activates C/EBP, thereby promoting the formation of long-term facilitation and behavioral sensitization.
摘要
突触可塑性的长期变化需要新的蛋白质合成。本综述讨论了Kim等人（本期《神经元》）的数据，这些数据表明一种新型核仁蛋白LLP（类LAPS18蛋白）对于海兔中长时程易化的形成是必需的。LLP与C/EBP结合并激活其转录，从而促进长时程易化和行为敏化的形成。
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