数字X线摄影测量法（DXR）在评估慢性炎症性肠病患儿骨质减少方面的潜力。
The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease.
作者信息
Mentzel Hans-Joachim, Blume Joerg, Boettcher Joachim, Lehmann Gabriele, Tuchscherer Diana, Pfeil Alexander, Kramer Anika, Malich Ansgar, Kauf Eberhard, Hein Gert, Kaiser Werner A
机构信息
Department of Pediatric Radiology, Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Bachstrasse 18, 07740, Jena, Germany.
出版信息
Pediatr Radiol. 2006 May;36(5):415-20. doi: 10.1007/s00247-005-0093-y. Epub 2006 Feb 28.
BACKGROUND
Loss of bone mass is a known complication of chronic inflammatory bowel disease (IBD) in children. The gold standard in the evaluation of bone mineral density (BMD) is dual energy X-ray absorptiometry (DXA).
OBJECTIVE
In this preliminary study we evaluated digital X-ray radiogrammetry (DXR) which estimates BMD (DXR-BMD) from hand radiographs in children with IBD.
MATERIALS AND METHODS
A total of 26 children with IBD (10 girls, 16 boys; age range 10-18 years) underwent DXR for the calculation of DXR-BMD and metacarpal index (DXR-MCI) using the Pronosco X-posure system. The results were compared with a local reference database and correlated with the results of DXA.
RESULTS
DXR-BMD was 0.36-0.56 g/cm(2) (median 0.46 g/cm(2)) in Crohn disease patients and 0.38-0.63 g/cm(2) (median 0.48 g/cm(2)) in ulcerative colitis patients. DXR-MCI was 0.29-0.49 in Crohn disease patients and 0.28-0.53 in ulcerative colitis patients. The Z-scores were reduced to <-1 SD in five Crohn disease patients and in six ulcerative colitis patients. The coefficients (r) for the correlations between DXR-BMD and DXA-BMD were 0.78 for the lumbar spine and 0.61 for the proximal femur (P<0.01), and between DXR-MCI and DXA-BMD were 0.78 for the lumbar spine and 0.51 for the proximal femur (P<0.01).
CONCLUSIONS
DXR seems to be able to estimate cortical osteopenia in children with chronic IBD. The DXR results showed a positive correlation with DXA results.
背景
骨质流失是儿童慢性炎症性肠病（IBD）的一种已知并发症。骨密度（BMD）评估的金标准是双能X线吸收法（DXA）。
目的
在这项初步研究中，我们评估了数字X线摄影测量法（DXR），该方法可通过IBD患儿的手部X线片估算骨密度（DXR-BMD）。
材料与方法
总共26例IBD患儿（10名女孩，16名男孩；年龄范围10 - 18岁）使用Pronosco X-posure系统接受DXR检查，以计算DXR-BMD和掌骨指数（DXR-MCI）。将结果与当地参考数据库进行比较，并与DXA结果相关联。
结果
克罗恩病患者的DXR-BMD为0.36 - 0.56 g/cm²（中位数0.46 g/cm²），溃疡性结肠炎患者为0.38 - 0.63 g/cm²（中位数0.48 g/cm²）。克罗恩病患者的DXR-MCI为0.29 - 0.49，溃疡性结肠炎患者为0.28 - 0.53。5例克罗恩病患者和6例溃疡性结肠炎患者的Z值降低至<-1 SD。DXR-BMD与DXA-BMD之间的相关性系数（r），腰椎为0.78，股骨近端为0.61（P<0.01）；DXR-MCI与DXA-BMD之间的相关性系数，腰椎为0.78，股骨近端为0.51（P<0.01）。
结论
DXR似乎能够估算慢性IBD患儿的皮质骨减少情况。DXR结果与DXA结果呈正相关。
Zotero 插件