宫颈转移性鳞状细胞癌导致的视神经病变：一种不寻常的中枢神经系统表现。
Optic neuropathy from metastatic squamous cell carcinoma of the cervix: an unusual CNS presentation.
作者信息
Portera Chia Chiao, Gottesman Rebecca F, Srodon Monica, Asrari Fariba, Dillon Michael, Armstrong Deborah K
机构信息
Department of Internal Medicine, Sinai Hospital of Baltimore, MD 21215, USA.
出版信息
Gynecol Oncol. 2006 Jul;102(1):121-3. doi: 10.1016/j.ygyno.2006.01.040. Epub 2006 Feb 28.
BACKGROUND
Central nervous system (CNS) metastases from cervical carcinoma are uncommon events. Leptomeningeal involvement from cervical squamous cell carcinoma has not been extensively described.
CASE
A 43-year-old woman with initial diagnosis of stage IB squamous cervical carcinoma at age 30 was treated with hysterectomy and left salpingo-oophorectomy. She recurred with nodal disease at age 39 and went into a clinical complete remission after chemotherapy and radiation treatment. Three years later, she presented with symptoms of optic neuropathy. Cerebral spinal fluid (CSF) was positive for squamous cells consistent with primary cervical squamous cell carcinoma. No measurable disease was evident outside of the CNS.
CONCLUSION
Meningeal carcinomatosis from cervical squamous cell carcinoma involving optic nerves has not been reported. Rapid progression of this patient's CNS metastatic disease suggests this form of metastases may be more aggressive and carry extremely poor prognosis.
背景
宫颈癌的中枢神经系统（CNS）转移并不常见。宫颈鳞状细胞癌的软脑膜受累尚未得到广泛描述。
病例
一名43岁女性，30岁时初诊为IB期宫颈鳞状癌，接受了子宫切除术和左侧输卵管卵巢切除术。39岁时出现淋巴结复发，化疗和放疗后达到临床完全缓解。三年后，她出现视神经病变症状。脑脊液（CSF）中鳞状细胞呈阳性，与原发性宫颈鳞状细胞癌一致。中枢神经系统外无明显可测量的病灶。
结论
宫颈鳞状细胞癌累及视神经的脑膜癌病尚未见报道。该患者中枢神经系统转移性疾病的快速进展表明这种转移形式可能更具侵袭性，预后极差。
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