磺达肝癸钠与依诺肝素对兔模型中充血性皮瓣存活的影响。
The effect of fondaparinux versus enoxaparin in the survival of a congested skin flap in a rabbit model.
作者信息
Chung Thomas L, Holton Luther H, Silverman Ronald P
机构信息
Division of Plastic and Reconstructive Surgery, University of Maryland Medical Center, Baltimore, 21201, USA.
出版信息
Ann Plast Surg. 2006 Mar;56(3):312-5. doi: 10.1097/01.sap.0000198550.72815.72.
BACKGROUND
The purpose of this study was to evaluate the effects of fondaparinux, a selective antithrombin III agonist, in comparison to the low-molecular-weight heparin enoxaparin in the survival of a congested skin flap.
MATERIALS AND METHODS
Eighteen axial-pattern auricular flaps were performed on rabbits using a well-described congested flap model. Animals were randomized into 2 treatment groups, enoxaparin (n = 6) and fondaparinux (n = 6), and a control group (n = 6) that received no treatment. Skin flap survival area was measured postoperatively at 7 and 14 days.
RESULTS
The groups that received fondaparinux and enoxaparin had similar mean flap survival areas and were not statistically different. However, both treatment groups significantly increased flap survival compared with controls (P < 0.014).
CONCLUSIONS
Fondaparinux, like enoxaparin, significantly improves survival of congested flaps in rabbits. Its use instead of enoxaparin may be warranted, given that it eliminates the risk of heparin-induced thrombocytopenia. Further study in humans is warranted.
背景
本研究旨在评估选择性抗凝血酶III激动剂磺达肝癸钠相较于低分子量肝素依诺肝素对充血皮瓣存活情况的影响。
材料与方法
采用一种广为人知的充血皮瓣模型，对家兔进行18次轴型耳廓皮瓣手术。将动物随机分为2个治疗组，依诺肝素组（n = 6）和磺达肝癸钠组（n = 6），以及一个未接受治疗的对照组（n = 6）。术后第7天和第14天测量皮瓣存活面积。
结果
接受磺达肝癸钠和依诺肝素治疗的组平均皮瓣存活面积相似，且无统计学差异。然而，与对照组相比，两个治疗组的皮瓣存活率均显著提高（P < 0.014）。
结论
与依诺肝素一样，磺达肝癸钠能显著提高家兔充血皮瓣的存活率。鉴于其消除了肝素诱导的血小板减少症的风险，使用它替代依诺肝素可能是合理的。有必要在人体中进行进一步研究。
Zotero 插件