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Ben May Institute for Cancer Research, 929 East 57(th) Street, CIS, W423U, Chicago, Illinois 60637, USA.

Dev Cell. 2006 Mar;10(3):277-8. doi: 10.1016/j.devcel.2006.02.006.

The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular Cell paper that transient JNK activation suppresses TNF-alpha-induced cell death.

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Ben May Institute for Cancer Research, 929 East 57(th) Street, CIS, W423U, Chicago, Illinois 60637, USA.

Dev Cell. 2006 Mar;10(3):277-8. doi: 10.1016/j.devcel.2006.02.006.

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A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action.

Dev Cell. 2006 Mar;10(3):277-8. doi: 10.1016/j.devcel.2006.02.006.

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs.

Cell Res. 2008 Oct;18(10):1020-36. doi: 10.1038/cr.2008.76.

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J Leukoc Biol. 2007 Nov;82(5):1344-52. doi: 10.1189/jlb.0407259. Epub 2007 Aug 20.

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

Oncogene. 2007 Feb 22;26(8):1201-12. doi: 10.1038/sj.onc.1209906. Epub 2006 Aug 21.

Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.

BMC Mol Biol. 2007 Jun 13;8:50. doi: 10.1186/1471-2199-8-50.

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Biochem Biophys Res Commun. 2006 Jun 16;344(4):1172-8. doi: 10.1016/j.bbrc.2006.03.180. Epub 2006 Apr 6.

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Toxicol Appl Pharmacol. 2007 May 1;220(3):311-9. doi: 10.1016/j.taap.2007.02.008. Epub 2007 Feb 24.

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Exp Cell Res. 2008 Feb 1;314(3):509-29. doi: 10.1016/j.yexcr.2007.10.005. Epub 2007 Oct 13.

Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

Biochem Pharmacol. 2006 Oct 30;72(9):1090-101. doi: 10.1016/j.bcp.2006.07.003. Epub 2006 Aug 24.

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引用本文的文献

A comprehensive review of hook. f. in the treatment of rheumatic and autoimmune diseases: Bioactive compounds, mechanisms of action, and future directions.

Front Pharmacol. 2023 Nov 1;14:1282610. doi: 10.3389/fphar.2023.1282610. eCollection 2023.

Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):574-583. doi: 10.1080/14756366.2020.1720013.

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Structure. 2012 Dec 5;20(12):2174-84. doi: 10.1016/j.str.2012.09.021. Epub 2012 Nov 8.

Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.

Int J Biochem Cell Biol. 2011 Mar;43(3):409-15. doi: 10.1016/j.biocel.2010.11.011. Epub 2010 Nov 21.

Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis.

J Biol Chem. 2010 Nov 5;285(45):34408-18. doi: 10.1074/jbc.M110.130989. Epub 2010 Sep 3.

Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.

J Biol Chem. 2008 Jul 25;283(30):20754-60. doi: 10.1074/jbc.M800024200. Epub 2008 May 9.

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