锥虫剪接前导序列帽4第2位的2'-O-甲基化由一种与痘苗病毒VP39相关的48 kDa蛋白质介导。 - Suppr

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超能文献

2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.

作者信息

Arhin George K, Ullu Elisabetta, Tschudi Christian

机构信息

Department of Internal Medicine, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536-0812, USA.

出版信息

Mol Biochem Parasitol. 2006 May;147(1):137-9. doi: 10.1016/j.molbiopara.2006.01.011. Epub 2006 Feb 17.

DOI:10.1016/j.molbiopara.2006.01.011

PMID:16516986

Abstract

摘要

相似文献

2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.

Mol Biochem Parasitol. 2006 May;147(1):137-9. doi: 10.1016/j.molbiopara.2006.01.011. Epub 2006 Feb 17.

Evidence that the RNA methylation and poly(A) polymerase stimulatory activities of vaccinia virus protein VP39 do not impinge upon one another.

Virology. 1998 Jul 5;246(2):253-65. doi: 10.1006/viro.1998.9209.

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Complete cap 4 formation is not required for viability in Trypanosoma brucei.

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Mechanism of RNA 2'-O-methylation: evidence that the catalytic lysine acts to steer rather than deprotonate the target nucleophile.

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引用本文的文献

Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4.

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Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.

Mol Cell Biol. 2013 May;33(10):1965-75. doi: 10.1128/MCB.00156-13. Epub 2013 Mar 11.

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2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.

作者信息

Arhin George K, Ullu Elisabetta, Tschudi Christian

机构信息

Department of Internal Medicine, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536-0812, USA.

出版信息

Mol Biochem Parasitol. 2006 May;147(1):137-9. doi: 10.1016/j.molbiopara.2006.01.011. Epub 2006 Feb 17.

DOI:10.1016/j.molbiopara.2006.01.011

PMID:16516986

Abstract

摘要

相似文献

2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.

Mol Biochem Parasitol. 2006 May;147(1):137-9. doi: 10.1016/j.molbiopara.2006.01.011. Epub 2006 Feb 17.

Evidence that the RNA methylation and poly(A) polymerase stimulatory activities of vaccinia virus protein VP39 do not impinge upon one another.

Virology. 1998 Jul 5;246(2):253-65. doi: 10.1006/viro.1998.9209.

RNA. 2006 Jan;12(1):53-62. doi: 10.1261/rna.2223406. Epub 2005 Nov 21.

Complete cap 4 formation is not required for viability in Trypanosoma brucei.

Eukaryot Cell. 2006 Jun;5(6):905-15. doi: 10.1128/EC.00080-06.

The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei.

Mol Cell Biol. 2007 Sep;27(17):6084-92. doi: 10.1128/MCB.00647-07. Epub 2007 Jul 2.

A polyadenylylation-specific RNA-contact site on the surface of the bifunctional vaccinia virus RNA modifying protein VP39 that is distinct from the mRNA 5' end-binding "cleft".

J Mol Biol. 1999 Jan 29;285(4):1417-27. doi: 10.1006/jmbi.1998.2417.

Functional characterization of a 48 kDa Trypanosoma brucei cap 2 RNA methyltransferase.

Nucleic Acids Res. 2006;34(19):5594-602. doi: 10.1093/nar/gkl573. Epub 2006 Oct 5.

Recognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase.

Biochemistry. 1998 Jun 9;37(23):8564-74. doi: 10.1021/bi980178m.

Mechanism of RNA 2'-O-methylation: evidence that the catalytic lysine acts to steer rather than deprotonate the target nucleophile.

Biochemistry. 2004 May 18;43(19):5680-7. doi: 10.1021/bi0359980.

Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex.

Mol Cell Biol. 2009 Mar;29(5):1202-11. doi: 10.1128/MCB.01496-08. Epub 2008 Dec 22.

引用本文的文献

Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4.

Nucleic Acids Res. 2024 Sep 23;52(17):10645-10653. doi: 10.1093/nar/gkae614.

CMTr mediated 2'--ribose methylation status of cap-adjacent nucleotides across animals.

RNA. 2022 Oct;28(10):1377-1390. doi: 10.1261/rna.079317.122. Epub 2022 Aug 15.

Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts.

Parasitology. 2021 Sep;148(10):1196-1218. doi: 10.1017/S0031182021000068. Epub 2021 Jan 19.

The messenger RNA decapping and recapping pathway in Trypanosoma.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6967-72. doi: 10.1073/pnas.1424909112. Epub 2015 May 18.

RNA methyltransferases involved in 5' cap biosynthesis.

RNA Biol. 2014;11(12):1597-607. doi: 10.1080/15476286.2015.1004955.

The spliceosomal PRP19 complex of trypanosomes.

Mol Microbiol. 2015 Mar;95(5):885-901. doi: 10.1111/mmi.12910. Epub 2015 Jan 30.

Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.

Mol Cell Biol. 2013 May;33(10):1965-75. doi: 10.1128/MCB.00156-13. Epub 2013 Mar 11.

Evolutionary conservation and diversification of the translation initiation apparatus in trypanosomatids.

Comp Funct Genomics. 2012;2012:813718. doi: 10.1155/2012/813718. Epub 2012 Jul 8.

2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.

Nucleic Acids Res. 2011 Jun;39(11):4756-68. doi: 10.1093/nar/gkr038. Epub 2011 Feb 9.

Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.

J Biol Chem. 2010 Oct 22;285(43):33037-33044. doi: 10.1074/jbc.M110.155283. Epub 2010 Aug 16.