Li Ji-sheng, Yang Fang, Zhao Xin
Martial Preventive Medicine Graduate School, Chinese People's Armed Police Force Medical College, Tianjin 300162,China.
Wei Sheng Yan Jiu. 2005 Nov;34(6):678-80.
To investigate the effects of lithium on brain development, leaning and memory, we observed the effects of lithium chloride on rat body weight, learning ability and memory capacity.
Wistar rats were randomly divided into control group and four lithium chloride (LiCl) groups. Four LiCl groups were feed with food containing 3, 30, 300, 3000 mg/kg LiCl respectively. Control group was feed with normal food. By means of measuring the body weight, using Y-maze test and ABC immunohistochemistry, we observed the difference of the body weight gains and Y-maze training times of different groups, and the changes of CCK positive neurons in hippocampus.
Compared with control group, 3, 30 mg/kg LiCl groups could increase the body weight and improve the ability of learning and memory of rats(P < 0.01), however, these of the rats of 300, 3000 mg/kg group were lower (P < 0.05). The numbers of CCK positive neurons in hippocampus of 3, 30, 300 mg/kg groups were significantly increased compared with control group (P < 0.05), that of 3000mg/kg group was lower than control group (P < 0.05).
Low dose of lithium can improve the growth, the learning ability and the memory capacity obviously, but high dose of lithium could result in harmful effects.
为研究锂对大脑发育、学习和记忆的影响，我们观察了氯化锂对大鼠体重、学习能力和记忆能力的影响。
将Wistar大鼠随机分为对照组和四个氯化锂（LiCl）组。四个LiCl组分别喂食含3、30、300、3000mg/kg LiCl的食物。对照组喂食正常食物。通过测量体重、使用Y迷宫试验和ABC免疫组织化学方法，我们观察了不同组大鼠体重增加量和Y迷宫训练次数的差异，以及海马中CCK阳性神经元的变化。
与对照组相比，3、30mg/kg LiCl组可增加大鼠体重并提高其学习和记忆能力（P<0.01），然而，300、3000mg/kg组大鼠的体重增加量和学习记忆能力较低（P<0.05）。3、30、300mg/kg组海马中CCK阳性神经元数量与对照组相比显著增加（P<0.05），3000mg/kg组低于对照组（P<0.05）。
低剂量锂可明显改善生长、学习能力和记忆能力，但高剂量锂可能产生有害影响。
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