Ernst E, Lauritsen J G
Department of Neurobiology, University of Aarhus, Denmark.
Pharmacol Toxicol. 1991 Jun;68(6):440-4. doi: 10.1111/j.1600-0773.1991.tb01267.x.
The effects of mercuric chloride and methyl mercuric chloride on the motility of human spermatozoa in vitro were investigated. Organic as well as inorganic mercury compounds decreased the percentage of motile spermatozoa. After 15 min. incubation with 40 microM mercuric chloride a significant decrease in sperm motility was observed. Less than 5% of spermatozoa were motile after 30 min. of exposure to 20 microM methyl mercuric chloride. These effects could not be attenuated by addition of 5 microM sodium selenite. The ultrastructural localization of mercury was demonstrated by autometallography. Silver-enhanced mercury deposits could be demonstrated only in spermatozoa exposed to inorganic mercury. In these cells mercury grains were most abundant in membranes of midpiece and tail.
研究了氯化汞和甲基汞对人精子体外运动能力的影响。有机汞化合物和无机汞化合物均降低了活动精子的百分比。在与40微摩尔氯化汞孵育15分钟后，观察到精子活力显著下降。暴露于20微摩尔甲基汞30分钟后，不到5%的精子仍有活动能力。添加5微摩尔亚硒酸钠并不能减弱这些影响。通过自动金属显影法证明了汞的超微结构定位。仅在暴露于无机汞的精子中能检测到银增强的汞沉积物。在这些细胞中，汞颗粒在中段和尾部的膜中最为丰富。
